Regulation by noncoding RNAs of local translation, injury responses, and pain in the peripheral nervous system.
Regulation by noncoding RNAs of local translation, injury responses, and pain in the peripheral nervous system.
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DOI：
10.1016/j.ynpai.2023.100119
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发表时间：
2023-01
期刊：
影响因子：
--
通讯作者：
Meffert, Mollie K
中科院分区：
文献类型：
--
作者：
Li, Xinbei;Jin, Daniel S;Eadara, Sreenivas;Caterina, Michael J;Meffert, Mollie K
神经性疼痛是由伤害性感受通路内的适应不良可塑性引起的。改变的mRNA翻译有助于支持伤害性可塑性和持续性疼痛的持久病理生理变化。非编码RNA（ncRNA）在损伤后外周组织局部蛋白质组的转录后调节中起重要作用。损伤后外周组织中失调的ncRNA可能有助于伤害性可塑性和神经性疼痛的产生。神经性疼痛是一种慢性疾病，由躯体感觉通路的损伤引起，导致病理性超敏反应。持续性疼痛可以被看作是适应不良可塑性的结果，像大多数持久形式的细胞可塑性一样，需要改变特定基因程序的表达。在蛋白质合成水平控制基因表达被广泛用于直接调节伤害性通路中活性和反应性的变化，并通过局部翻译为外周神经中蛋白质组的区室化调节提供了有效机制。非编码RNA（ncRNA）的水平通常受到周围神经损伤的影响，导致持续性疼痛。NcRNA对局部蛋白质组发挥时空调节作用，并影响支持改变的感觉反应的信号级联，从而导致痛觉过敏。本文综述了周围神经系统（PNS）中发现的神经损伤后失调的ncRNA及其在病理生理疼痛相关反应中的作用，包括神经免疫相互作用，神经元存活和轴突再生，雪旺细胞去分化和增殖，细胞间通讯，以及初级传入神经中异位动作电位的产生。我们回顾了编目以外的领域的进展，重点是相关的目标转录本和ncRNA的疼痛调制机制。
Neuropathic pain results from maladaptive plasticity within nociceptive pathways. Altered mRNA translation contributes to the enduring pathophysiological changes supporting nociceptive plasticity and persistent pain. Noncoding RNAs (ncRNAs) play essential roles in post-transcriptional regulation of local proteomes in peripheral tissue following injury. ncRNAs that are dysregulated in peripheral tissue following injury could contribute to nociceptive plasticity and the generation of neuropathic pain. Neuropathic pain is a chronic condition arising from damage to somatosensory pathways that results in pathological hypersensitivity. Persistent pain can be viewed as a consequence of maladaptive plasticity which, like most enduring forms of cellular plasticity, requires altered expression of specific gene programs. Control of gene expression at the level of protein synthesis is broadly utilized to directly modulate changes in activity and responsiveness in nociceptive pathways and provides an effective mechanism for compartmentalized regulation of the proteome in peripheral nerves through local translation. Levels of noncoding RNAs (ncRNAs) are commonly impacted by peripheral nerve injury leading to persistent pain. NcRNAs exert spatiotemporal regulation of local proteomes and affect signaling cascades supporting altered sensory responses that contribute to hyperalgesia. This review discusses ncRNAs found in the peripheral nervous system (PNS) that are dysregulated following nerve injury and the current understanding of their roles in pathophysiological pain-related responses including neuroimmune interactions, neuronal survival and axon regeneration, Schwann cell dedifferentiation and proliferation, intercellular communication, and the generation of ectopic action potentials in primary afferents. We review progress in the field beyond cataloging, with a focus on the relevant target transcripts and mechanisms underlying pain modulation by ncRNAs.
大鼠中突触素增加参与细胞周期蛋白依赖性激酶 5 介导的炎症引起的热痛觉过敏
影响因子：
3.7
作者：
Zhang HH;Zhang XQ;Wang WY;Xue QS;Lu H;Huang JL;Gui T;Yu BW
通讯作者：
Yu BW
影响因子：
--
作者：
Chen Y;Chen S;Zhang J;Wang Y;Jia Z;Zhang X;Han X;Guo X;Sun X;Shao C;Wang J;Lan T
通讯作者：
Lan T