Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery.
Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery.
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DOI：
10.1002/adfm.201200864
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发表时间：
2012-12-05
影响因子：
19
通讯作者：
Woolfson, A. David
中科院分区：
文献类型：
--
作者：
Donnelly, Ryan F.;Singh, Thakur Raghu Raj;Garland, Martin J.;Migalska, Katarzyna;Majithiya, Rita;McCrudden, Cian M.;Kole, Prashant Laxman;Mahmood, Tuan Mazlelaa Tuan;McCarthy, Helen O.;Woolfson, A. David
描述了由交联聚合物制备的独特的微针阵列，其本身不含药物。它们在皮肤插入后迅速吸收皮肤间质液，以形成从附着的贴片型药物储库到真皮微循环的连续的、不可堵塞的水凝胶导管。重要的是，可以以宽范围的贴片尺寸和微针几何形状制造的这种微针可以容易地灭菌，在就位时抵抗孔闭合，并且从皮肤上完全完整地移除。大分子的递送不再限于可以装载到微针本身中的物质，并且透皮药物递送现在由水凝胶系统的交联密度而不是角质层控制，而电调制递送也是一个独特的特征。该技术有可能克服传统微针设计的局限性，并大大增加可透皮递送的药物类型的范围，从而为行业、医疗保健提供者以及最终患者带来益处。
Unique microneedle arrays prepared from crosslinked polymers, which contain no drug themselves, are described. They rapidly take up skin interstitial fluid upon skin insertion to form continuous, unblockable, hydrogel conduits from attached patch-type drug reservoirs to the dermal microcirculation. Importantly, such microneedles, which can be fabricated in a wide range of patch sizes and microneedle geometries, can be easily sterilized, resist hole closure while in place, and are removed completely intact from the skin. Delivery of macromolecules is no longer limited to what can be loaded into the microneedles themselves and transdermal drug delivery is now controlled by the crosslink density of the hydrogel system rather than the stratum corneum, while electrically modulated delivery is also a unique feature. This technology has the potential to overcome the limitations of conventional microneedle designs and greatly increase the range of the type of drug that is deliverable transdermally, with ensuing benefits for industry, healthcare providers and, ultimately, patients.
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影响因子：
3.4
作者：
Donnelly RF;Morrow DI;Singh TR;Migalska K;McCarron PA;O'Mahony C;Woolfson AD
通讯作者：
Woolfson AD
影响因子：
8.8
作者：
Bodian, CA;Freedman, G;Beilin, Y
通讯作者：
Beilin, Y
影响因子：
10.8
作者：
Donnelly, RF;McCarron, PA;Woolfson, AD
通讯作者：
Woolfson, AD
影响因子：
2.8
作者：
Haq, M. I.;Smith, E.;Birchall, J. C.
通讯作者：
Birchall, J. C.
影响因子：
3.7
作者：
Kalluri, Haripriya;Banga, Ajay K.
通讯作者：
Banga, Ajay K.