Odor representations in olfactory cortex: distributed rate coding and decorrelated population activity.

Odor representations in olfactory cortex: distributed rate coding and decorrelated population activity.
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DOI:
10.1016/j.neuron.2012.04.021
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发表时间:
2012-06-21
期刊:
影响因子:
16.2
通讯作者:
Uchida N
Uchida N
中科院分区:
医学1区
文献类型:
--
作者:
Miura K;Mainen ZF;Uchida N

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如何使用神经元尖峰序列中编码的信息来指导感官决策是一个基本问题。在嗅觉方面,一次嗅就足以辨别精细的气味,但嗅觉决策所依据的神经表征尚不清楚。在这里,我们记录了执行气味混合物分类任务的大鼠前梨状皮层(aPC)的神经整体活动。我们表明,气味会引起锁定在嗅觉开始的瞬时爆发,并且使用突发尖峰计数比尖峰延迟或时间模式可以更好地解码气味身份。令人惊讶的是,aPC 系综在气味刺激期间也表现出接近于零的噪声相关性。因此,不到 100 个 aPC 神经元提供了足够的信息来解释行为速度和准确性,这表明行为性能限制出现在 aPC 下游。这些发现证明了从嗅球到皮质的气味表征动态发生了深刻的转变,并揭示了气味引导决策的可能基础。
How information encoded in neuronal spike trains is used to guide sensory decisions is a fundamental question. In olfaction, a single sniff is sufficient for fine odor discrimination but the neural representations on which olfactory decisions are based are unclear. Here, we recorded neural ensemble activity in the anterior piriform cortex (aPC) of rats performing an odor mixture categorization task. We show that odors evoke transient bursts locked to sniff onset and that odor identity can be better decoded using burst spike counts than by spike latencies or temporal patterns. Surprisingly, aPC ensembles also exhibited near-zero noise correlations during odor stimulation. Consequently, fewer than 100 aPC neurons provided sufficient information to account for behavioral speed and accuracy, suggesting that behavioral performance limits arise downstream of aPC. These findings demonstrate profound transformations in the dynamics of odor representations from the olfactory bulb to cortex and reveal likely substrates for odor-guided decisions.
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