Multiple omics uncovers host-gut microbial mutualism during prebiotic fructooligosaccharide supplementation.
Multiple omics uncovers host-gut microbial mutualism during prebiotic fructooligosaccharide supplementation.
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DOI：
10.1093/dnares/dsu013
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发表时间：
2014-10
期刊：
影响因子：
--
通讯作者：
Ohno H
中科院分区：
文献类型：
--
作者：
Kato T;Fukuda S;Fujiwara A;Suda W;Hattori M;Kikuchi J;Ohno H
低聚果糖（FOS）是一种因具有促进健康的特性而闻名的益生元，它很可能通过改变微生物组成来改善人体肠道生态系统。然而，低聚果糖调节肠道生态系统的详细作用机制仍不清楚。由于个体间存在较大差异，传统的微生物和代谢物分析方法几乎无法显示出任何显著特征，但我们新的微生物 - 代谢物相关性方法，结合粪便免疫球蛋白A（IgA）测量，揭示了补充低聚果糖诱导的黏膜IgA与特定细菌的存在相关。此外，丁酸、L - 苯丙氨酸、L - 赖氨酸和酪胺的代谢动态与这些细菌以及IgA的产生呈正相关，而对甲酚呈负相关。综上所述，我们采用组学方法进行的聚焦个体内分析是揭示肠道分子网络的有力策略，并可为理解人体肠道生态系统提供新的视角。
Fructooligosaccharide (FOS), a prebiotic well known for its health-promoting properties, can improve the human gut ecosystem most likely through changes in its microbial composition. However, the detailed mechanism(s) of action of FOS in the modulation of the gut ecosystem remain(s) obscure. Traditional methods of profiling microbes and metabolites could barely show any significant features due to the existence of large interindividual differences, but our novel microbe–metabolite correlation approach, combined with faecal immunoglobulin A (IgA) measurements, has revealed that the induction of mucosal IgA by FOS supplementation correlated with the presence of specific bacteria. Furthermore, the metabolic dynamics of butyrate, l-phenylalanine, l-lysine and tyramine were positively correlated with that of these bacteria and IgA production, whereas p-cresol was negatively correlated. Taken together, our focused intraindividual analysis with omics approaches is a powerful strategy for uncovering the gut molecular network and could provide a new vista for understanding the human gut ecosystem.
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影响因子：
2.8
作者：
Date, Yasuhiro;Nakanishi, Yumiko;Kikuchi, Jun
通讯作者：
Kikuchi, Jun
影响因子：
3.7
作者：
Fukuda S;Nakanishi Y;Chikayama E;Ohno H;Hino T;Kikuchi J
通讯作者：
Kikuchi J
影响因子：
1.6
作者：
Hosono, A;Ozawa, A;Nakamura, R
通讯作者：
Nakamura, R
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
3.6
作者：
De Preter, V;Geboes, K;Verbeke, K
通讯作者：
Verbeke, K