Chromatin signatures of cancer.
Chromatin signatures of cancer.
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DOI：
10.1101/gad.255182.114
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发表时间：
2015-02-01
影响因子：
10.5
通讯作者：
Shilatifard A
中科院分区：
文献类型：
--
作者：
Morgan MA;Shilatifard A
癌症基因组联盟的研究已经确定了人类癌症中染色质调节因子和组蛋白的频繁突变，暗示它们是血液恶性肿瘤和实体肿瘤发病的主要介质。在这里，Morgan和Shilatifard回顾了我们对染色质在癌症中的作用的理解的最新进展，重点是转录调节复合物、增强子相关因子、组蛋白点突变和异染色质相互作用因子的改变。基因表达模式的改变在使癌细胞获得其标志性特征方面发挥着重要作用，而基因组的不稳定性使细胞获得促进肿瘤发生的遗传改变。染色质在转录调控和基因组稳定性的维持中起着核心作用。癌症基因组联盟的研究已经确定了人类癌症中编码染色质调节因子和组蛋白的基因的频繁突变，暗示它们是血液恶性肿瘤和实体肿瘤发病的主要介质。在这里，我们回顾了染色质在癌症中作用的最新进展，重点关注转录调控复合物、增强子相关因子、组蛋白点突变和异染色质相互作用因子的改变。
Studies by cancer genome consortiums have identified frequent mutations in chromatin regulatory factors and histone proteins in human cancer, implicating them as major mediators in the pathogenesis of both hematological malignancies and solid tumors. Here, Morgan and Shilatifard review recent advances in our understanding of the role of chromatin in cancer, focusing on transcriptional regulatory complexes, enhancer-associated factors, histone point mutations, and alterations in heterochromatin-interacting factors. Changes in the pattern of gene expression play an important role in allowing cancer cells to acquire their hallmark characteristics, while genomic instability enables cells to acquire genetic alterations that promote oncogenesis. Chromatin plays central roles in both transcriptional regulation and the maintenance of genomic stability. Studies by cancer genome consortiums have identified frequent mutations in genes encoding chromatin regulatory factors and histone proteins in human cancer, implicating them as major mediators in the pathogenesis of both hematological malignancies and solid tumors. Here, we review recent advances in our understanding of the role of chromatin in cancer, focusing on transcriptional regulatory complexes, enhancer-associated factors, histone point mutations, and alterations in heterochromatin-interacting factors.
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