SWIR emissive RosIndolizine dyes with nanoencapsulation in water soluble dendrimers.
SWIR emissive RosIndolizine dyes with nanoencapsulation in water soluble dendrimers.
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短波红外（SWIR）发射在高分辨率的深部组织生物成像中具有很大的潜力。本文介绍了两种新型杂蒽基rosindine染料PhRosIndz和tolRosIndz的合成和表征。通过飞秒瞬态吸收光谱、稳态吸收光谱和发射光谱对染料进行了表征。这些染料的发射显示在SWIR区域，峰值发射在1097 nm。TolRosIndz包被编码为10-PhPCL-G3的两亲性线性枝晶嵌段共聚物（LDBC），具有较高的吸收率。此外，使用HEK（人胚胎肾）细胞进行体外细胞毒性测试，在实际浓度下，包封染料的细胞存活率为> - 90%，表明毒性低，生物相容性合理。一种杂蒽-吲哚嗪染料被纳米封装后，在水中发射短波红外光谱区（最大约1100nm）。
Shortwave infrared (SWIR) emission has great potential for deep-tissue in vivo biological imaging with high resolution. In this article, the synthesis and characterization of two new xanthene-based RosIndolizine dyes coded PhRosIndz and tolRosIndz is presented. The dyes are characterized via femtosecond transient absorption spectroscopy as well as steady-state absorption and emission spectroscopies. The emission of these dyes is shown in the SWIR region with peak emission at 1097 nm. TolRosIndz was encapsulated with an amphiphilic linear dendritic block co-polymer (LDBC) coded 10-PhPCL-G3 with high uptake yield. Further, cellular toxicity was examined in vitro using HEK (human embryonic kidney) cells where a >90% cell viability was observed at practical concentrations of the encapsulated dye which indicates low toxicity and reasonable biocompatibility. A xanthene–indolizine dye is shown to emit in the shortwave infrared spectral region (∼1100 nm maximum) in water when nanoencapsulated.
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DOI：
10.1073/pnas.0707654105
发表时间：
2008-02-05
影响因子：
11.1
作者：
Liu, Zhuang;Davis, Corrine;Dai, Hongjie
通讯作者：
Dai, Hongjie
影响因子：
16.6
作者：
Lu, Lingfei;Li, Benhao;Zhang, Fan
通讯作者：
Zhang, Fan
影响因子：
15
作者：
Li, Mingle;Long, Saran;Peng, Xiaojun
通讯作者：
Peng, Xiaojun
影响因子：
48
作者：
Grimm JB;Muthusamy AK;Liang Y;Brown TA;Lemon WC;Patel R;Lu R;Macklin JJ;Keller PJ;Ji N;Lavis LD
通讯作者：
Lavis LD
影响因子：
2.9
作者：
Lavis, Luke D.
通讯作者：
Lavis, Luke D.