Diagnostic value of microRNA for pancreatic cancer: a meta-analysis.
Diagnostic value of microRNA for pancreatic cancer: a meta-analysis.
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DOI：
10.5114/aoms.2012.31609
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发表时间：
2012-11-09
期刊：
影响因子：
--
通讯作者：
Wen F
中科院分区：
文献类型：
--
作者：
Wan C;Shen Y;Yang T;Wang T;Chen L;Wen F
已有报道称，胰腺癌患者体内存在microRNAs的异常表达。本荟萃分析的目的是建立微小RNA检测在胰腺癌诊断中的总体诊断准确性。在对Medline、Embase和Cochrane图书馆的英语语言研究进行系统综述后，使用随机效应模型汇集了microRNA在胰腺癌诊断中的敏感性、特异性和其他准确性指标。每项研究的方法学质量通过QUADAS(诊断准确性研究的质量评估)进行评估。采用Meta-Disc 1.4软件和STATA软件进行统计分析。使用概要接收器工作特性曲线来总结总体测试性能。使用Deek‘s检验来检验潜在的发表偏倚。来自7个出版物的9项研究符合我们的纳入标准。这些研究对microRNAs诊断胰腺癌的综合估计为：合并敏感性0.89(95%CI：0.86~0.91)，特异性0.93(95%CI：0.9~0.95)，阳性似然比11.62(95%CI：5.75~23.50)，阴性似然比0.14(95%CI：0.08~0.24)，诊断优势比115.13(95%CI：33.73~351.28)，曲线下面积0.97。MicroRNA检测在胰腺癌的诊断中具有重要意义。对microRNA检测结果的解释应与临床结果和常规检测结果相一致。
MicroRNAs have been reported to be aberrantly expressed in patients with pancreatic cancer. The aim of the present meta-analysis is to establish the overall diagnostic accuracy of the measurement of microRNA for diagnosing pancreatic cancer. After a systematic review of English language studies from Medline, Embase, and Cochrane Library, the sensitivity, specificity, and other measures of accuracy of microRNA in the diagnosis of pancreatic cancer were pooled using random-effects models. The methodological quality of each study was assessed by QUADAS (quality assessment for studies of diagnostic accuracy). Statistical analysis was performed by employing Meta-Disc 1.4 software and STATA. Summary receiver operating characteristic curves were used to summarize overall test performance. Deeks’ test was used to test the potential publication bias. Nine studies from seven publications met our inclusion criteria. The summary estimates for microRNAs in the diagnosis of pancreatic cancer in these studies were pooled sensitivity 0.89 (95% CI: 0.86-0.91), specificity 0.93 (95% CI: 0.90-0.95), positive likelihood ratio 11.62 (95% CI: 5.75-23.50), negative likelihood ratio 0.14 (95% CI: 0.08-0.24), diagnostic odds ratio 115.13 (95% CI: 33.73-351.28), and the area under the curve was 0.97. MicroRNA assay plays an important role in the diagnosis of pancreatic cancer. The results of microRNA assays should be interpreted in parallel with clinical findings and the results of conventional tests.
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