Memory Consolidation Is Linked to Spindle-Mediated Information Processing during Sleep.
Memory Consolidation Is Linked to Spindle-Mediated Information Processing during Sleep.
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DOI：
10.1016/j.cub.2018.01.087
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发表时间：
2018-03-19
期刊：
影响因子：
--
通讯作者：
Staresina BP
中科院分区：
文献类型：
--
作者：
Cairney SA;Guttesen AÁV;El Marj N;Staresina BP
短暂的相遇如何转化为永恒的记忆？先前的研究已经确定了非快速眼动（NREM）睡眠的作用，沿着其慢振荡（SO）和纺锤波的电生理特征，用于记忆巩固。在相关的工作中，实验操作已经证明，NREM睡眠提供了一个机会窗口，通过听觉线索的传递选择性地加强特定的记忆痕迹，这一过程被称为目标记忆再激活（TMR）。然而，目前尚不清楚TMR是否触发大脑的内源性巩固机制（与SO和/或纺锤体有关），以及这些机制是否反过来介导记忆信息的有效处理。我们设计了一种新的范式，其中联想记忆（形容词-对象和形容词-场景对）在学习后小睡期间被选择性地提示，成功地稳定了第二天相对于非提示记忆的保留。首先，我们发现，与新的控制形容词相比，记忆线索诱发了快速纺锤波的增加。关键的是，在线索诱导的纺锤体活动的时间窗内，与言语线索（对象或场景）相关的记忆类别可以被可靠地解码，这种解码的保真度预测了TMR的行为巩固益处。这些结果为睡眠纺锤波在记忆巩固中的信息加工作用提供了相关证据。我们提示睡眠中的记忆再激活，以调查的功能性作用的纺锤体记忆提示支持检索性能的第二天相对于控制刺激，记忆线索诱发了激增的快速纺锤体活动记忆内容可以可靠地解码在此期间增加纺锤体睡眠中发挥着至关重要的作用，记忆巩固，但其潜在的机制还没有得到很好的理解。使用听觉记忆提示技术和脑电图分析在人类，Cairney等人。表明睡眠纺锤波介导了离线记忆处理中重新激活记忆痕迹的信息内容。
How are brief encounters transformed into lasting memories? Previous research has established the role of non-rapid eye movement (NREM) sleep, along with its electrophysiological signatures of slow oscillations (SOs) and spindles, for memory consolidation. In related work, experimental manipulations have demonstrated that NREM sleep provides a window of opportunity to selectively strengthen particular memory traces via the delivery of auditory cues, a procedure known as targeted memory reactivation (TMR). It has remained unclear, however, whether TMR triggers the brain’s endogenous consolidation mechanisms (linked to SOs and/or spindles) and whether those mechanisms in turn mediate effective processing of mnemonic information. We devised a novel paradigm in which associative memories (adjective-object and adjective-scene pairs) were selectively cued during a post-learning nap, successfully stabilizing next-day retention relative to non-cued memories. First, we found that, compared to novel control adjectives, memory cues evoked an increase in fast spindles. Critically, during the time window of cue-induced spindle activity, the memory category linked to the verbal cue (object or scene) could be reliably decoded, with the fidelity of this decoding predicting the behavioral consolidation benefits of TMR. These results provide correlative evidence for an information processing role of sleep spindles in service of memory consolidation. We cued memory reactivation in sleep to investigate the functional role of spindles Memory cueing bolstered retrieval performance the following day Relative to control stimuli, memory cues evoked a surge in fast spindle activity Memory content could be reliably decoded during this spindle increase Sleep spindles play a crucial role in memory consolidation, but the underlying mechanisms are not well understood. Using an auditory memory-cueing technique and EEG analysis in humans, Cairney et al. show that sleep spindles mediate the informational content of reactivated memory traces in service of offline mnemonic processing.
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影响因子：
5.3
作者：
Rosanova, M;Ulrich, D
通讯作者：
Ulrich, D
DOI：
10.1126/science.1179013
发表时间：
2009-11-20
期刊：
Science (New York, N.Y.)
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--
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作者：
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