The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics.
The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics.
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DOI：
10.1126/scitranslmed.3001862
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发表时间：
2011-04-27
影响因子：
17.1
通讯作者：
Austin CP
中科院分区：
文献类型：
--
作者：
Huang R;Southall N;Wang Y;Yasgar A;Shinn P;Jadhav A;Nguyen DT;Austin CP
被批准作为药物使用的小分子化合物可能被“重新利用”用于新的适应症，并被研究以确定其有益和不良作用的机制。全面收集批准供人使用的所有小分子药物，对于系统地重新利用人类疾病，特别是罕见和被忽视的疾病，将是非常宝贵的，因为开发一种新的化学实体所需的成本和时间往往令人望而却步。以前建立这样一个全面的集合的努力受到世界各地监管机构内部和之间药物命名的复杂性、冗余和语义不一致的限制；对什么是毒品缺乏明确的概念；以及无法接触到实物样本。我们在此报告创建了一个明确的、完整的、无冗余的所有批准的分子实体列表，作为一个免费的电子资源和一个适合高通量筛选的小分子的物理集合。
Small-molecule compounds approved for use as drugs may be “repurposed” for new indications and studied to determine the mechanisms of their beneficial and adverse effects. A comprehensive collection of all small-molecule drugs approved for human use would be invaluable for systematic repurposing across human diseases, particularly for rare and neglected diseases, for which the cost and time required for development of a new chemical entity are often prohibitive. Previous efforts to build such a comprehensive collection have been limited by the complexities, redundancies, and semantic inconsistencies of drug naming within and among regulatory agencies worldwide; a lack of clear conceptualization of what constitutes a drug; and a lack of access to physical samples. We report here the creation of a definitive, complete, and nonredundant list of all approved molecular entities as a freely available electronic resource and a physical collection of small molecules amenable to high-throughput screening.
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DOI：
10.1038/nrd2030
发表时间：
2006-08
期刊：
Nature reviews. Drug discovery
影响因子：
--
作者：
Ghofrani HA;Osterloh IH;Grimminger F
通讯作者：
Grimminger F
影响因子：
2.2
作者：
DiMasi, Joseph A.;Grabowski, Henry G.
通讯作者：
Grabowski, Henry G.
影响因子：
14.8
作者：
Chong, Curtis R.;Chen, Xiaochun;Sullivan, David J., Jr.
通讯作者：
Sullivan, David J., Jr.
影响因子：
7.3
作者：
Auld, Douglas S.;Southall, Noel T.;Inglese, James
通讯作者：
Inglese, James
DOI：
10.1073/pnas.0604348103
发表时间：
2006-08-01
影响因子：
11.1
作者：
Inglese, James;Auld, Douglas S.;Austin, Christopher P.
通讯作者：
Austin, Christopher P.