Light- and dopamine-regulated receptive field plasticity in primate horizontal cells.
Light- and dopamine-regulated receptive field plasticity in primate horizontal cells.
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DOI：
10.1002/cne.22604
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发表时间：
2011-08-01
影响因子：
2.5
通讯作者：
Wu, Samuel M.
中科院分区：
文献类型：
--
作者：
Zhang, Ai-Jun;Jacoby, Roy;Wu, Samuel M.
中心-环绕拮抗感受野（CSARF）是空间视觉和对比度感知的基石。视网膜水平细胞（RetinalHorizontalCells，HC）是视觉通路的第一个沿着成分，被认为参与了高级神经元的感受野包围。灵长类HC感受野尚未发现改变与光，多巴胺能调制尚未进行研究。在暗适应猕猴视网膜中对HC进行细胞内记录，我们发现H1-HC具有大的感受野（λ = 1，158 ± 137 μm），其被背景光（-45%）、间隙连接闭合（-53%）和D1多巴胺受体激活（-48%）降低。示踪剂耦合调制的相关方式，表明耦合电阻起着主导作用，在弱光条件下的感受野形成。D1拮抗剂SCH 23390增加了感受野的大小（+13%），表明在黑暗中多巴胺的紧张性释放。由于光升高多巴胺释放在灵长类动物视网膜，我们的研究结果支持多巴胺能的作用后受体光适应减少HC感受野直径，这影响了中心周围的高阶神经元感受野组织，从而空间对比敏感度。
Center-surround antagonistic receptive fields (CSARFs) are building blocks for spatial vision and contrast perception. Retinal horizontal cells (HCs) are the first lateral elements along the visual pathway, and are thought to contribute to receptive field surrounds of higher order neurons. Primate HC receptive fields have not been found to change with light, and dopaminergic modulation has not been investigated. Recording intracellularly from HCs in dark-adapted macaque retina, we found that H1-HCs had large receptive fields (λ = 1,158 ± 137 μm) that were reduced by background light (–45%), gap junction closure (–53%), and D1 dopamine receptor activation (–48%). Tracer coupling was modulated in a correlative manner, suggesting that coupling resistance plays a dominant role in receptive field formation under low light conditions. The D1 antagonist SCH23390 increased the size of receptive fields (+13%), suggesting tonic dopamine release in the dark. Because light elevates dopamine release in primate retina, our results support a dopaminergic role in post-receptoral light adaptation by decreasing HC receptive field diameters, which influences the center-surround receptive field organization of higher-order neurons and thereby spatial contrast sensitivity.
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