Opportunities in multidimensional trace metal imaging: taking copper-associated disease research to the next level.
Opportunities in multidimensional trace metal imaging: taking copper-associated disease research to the next level.
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DOI：
10.1007/s00216-012-6437-1
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发表时间：
2013-02
影响因子：
4.3
通讯作者：
Ralle, Martina
中科院分区：
文献类型：
--
作者：
Vogt, Stefan;Ralle, Martina
铜在所有生命系统的许多生物过程中起着重要作用，主要是因为它的多用途氧化还原行为。细胞铜稳态受到严格调控，干扰可导致严重的疾病，如Wilson病（WD）和Menkes病。与年龄相关的铜代谢变化与其他神经退行性疾病如阿尔茨海默病（AD）有关。十多年来，铜在这些疾病中的作用一直是生物无机研究的主题，金属-蛋白质相互作用已经被表征，细胞铜途径已经被描述。尽管做出了这些努力，但铜与阿尔茨海默病之间关系的关键方面，例如，仍然知之甚少。为了将金属相关疾病的研究提升到一个新的水平，新兴的多维成像技术正在揭示铜金属组作为更好地了解疾病机制的基础。本文将介绍x射线荧光显微镜和荧光铜探针的最新进展如何开始对这一领域特别是WD和AD做出贡献。它进一步提供了当前的发展概况和未来的应用在x射线显微方法。
Copper plays an important role in numerous biological processes across all living systems predominantly because of its versatile redox behavior. Cellular copper homeostasis is tightly regulated and disturbances lead to severe disorders such as Wilson disease (WD) and Menkes disease. Age related changes of copper metabolism have been implicated in other neurodegenerative disorders such as Alzheimer’s disease (AD). The role of copper in these diseases has been topic of mostly bioinorganic research efforts for more than a decade, metal-protein interactions have been characterized and cellular copper pathways have been described. Despite these efforts, crucial aspects of how copper is associated with AD, for example, is still only poorly understood. To take metal related disease research to the next level, emerging multi dimensional imaging techniques are now revealing the copper metallome as the basis to better understand disease mechanisms. This review will describe how recent advances in X-ray fluorescence microscopy and fluorescent copper probes have started to contribute to this field specifically WD and AD. It furthermore provides an overview of current developments and future applications in X-ray microscopic methodologies.
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影响因子：
30.8
作者：
BULL, PC;THOMAS, GR;COX, DW
通讯作者：
COX, DW
DOI：
10.1126/science.1217737
发表时间：
2012-07-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Boutet S;Lomb L;Williams GJ;Barends TR;Aquila A;Doak RB;Weierstall U;DePonte DP;Steinbrener J;Shoeman RL;Messerschmidt M;Barty A;White TA;Kassemeyer S;Kirian RA;Seibert MM;Montanez PA;Kenney C;Herbst R;Hart P;Pines J;Haller G;Gruner SM;Philipp HT;Tate MW;Hromalik M;Koerner LJ;van Bakel N;Morse J;Ghonsalves W;Arnlund D;Bogan MJ;Caleman C;Fromme R;Hampton CY;Hunter MS;Johansson LC;Katona G;Kupitz C;Liang M;Martin AV;Nass K;Redecke L;Stellato F;Timneanu N;Wang D;Zatsepin NA;Schafer D;Defever J;Neutze R;Fromme P;Spence JC;Chapman HN;Schlichting I
通讯作者：
Schlichting I
DOI：
10.1073/pnas.0600213103
发表时间：
2006-06-27
影响因子：
11.1
作者：
Chen, Kevin G.;Valencia, Julio C.;Gottesman, Michael M.
通讯作者：
Gottesman, Michael M.
影响因子：
8.6
作者：
de Jonge, M. D.;Homberger, B.;Vogt, S.
通讯作者：
Vogt, S.
影响因子：
4.7
作者：
Endres, Paul J.;MacRenaris, Keith W.;Vogt, Stefan;Meade, Thomas J.
通讯作者：
Meade, Thomas J.