Chronic stress may facilitate the recruitment of habit- and addiction-related neurocircuitries through neuronal restructuring of the striatum.
Chronic stress may facilitate the recruitment of habit- and addiction-related neurocircuitries through neuronal restructuring of the striatum.
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DOI：
10.1016/j.neuroscience.2014.09.029
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发表时间：
2014-11-07
期刊：
影响因子：
3.3
通讯作者：
Conrad, C. D.
中科院分区：
文献类型：
--
作者：
Taylor, S. B.;Anglin, J. M.;Paode, P. R.;Riggert, A. G.;Olive, M. F.;Conrad, C. D.
慢性压力是成瘾发展的既定危险因素。成瘾的特点是从随意吸毒逐渐过渡到习惯性和强迫性吸毒。慢性压力促进成瘾转变的能力可能是通过增加习惯性行为和成瘾背后的神经回路的参与来介导的。在本研究中，对雄性斯普拉格-道利大鼠慢性可变应激两周后的纹状体形态进行了评估。通过高尔基染色对背外侧和背内侧纹状体以及伏隔核核和壳中的中型多刺神经元的树突复杂性进行可视化和定量。在单独的队列中，还评估了慢性压力对习惯行为的影响以及对甲基苯丙胺的急性运动反应。慢性压力导致背外侧纹状体和伏隔核核心（与习惯行为和成瘾有关的区域）的树突复杂性增加，而伏隔核壳（对滥用药物的最初奖赏效应至关重要的区域）的复杂性降低。慢性应激不影响背内侧纹状体的树突复杂性。还发现了慢性压力后向习惯性学习策略的平行转变。对甲基苯丙胺的急性运动反应最初有所减少，但由于长期压力暴露而没有持久影响。这些发现表明，慢性压力可能通过纹状体中的神经元重组促进与习惯和成瘾相关的神经回路的募集。
Chronic stress is an established risk factor in the development of addiction. Addiction is characterized by a progressive transition from casual drug use to habitual and compulsive drug use. The ability of chronic stress to facilitate the transition to addiction may be mediated by increased engagement of the neurocircuitries underlying habitual behavior and addiction. In the present study, striatal morphology was evaluated after two weeks of chronic variable stress in male Sprague-Dawley rats. Dendritic complexity of medium spiny neurons was visualized and quantified with Golgi staining in the dorsolateral and dorsomedial striatum, as well as in the nucleus accumbens core and shell. In separate cohorts, the effects of chronic stress on habitual behavior and the acute locomotor response to methamphetamine were also assessed. Chronic stress resulted in increased dendritic complexity in the dorsolateral striatum and nucleus accumbens core, regions implicated in habitual behavior and addiction, while decreased complexity was found in the nucleus accumbens shell, a region critical for the initial rewarding effects of drugs of abuse. Chronic stress did not affect dendritic complexity in the dorsomedial striatum. A parallel shift toward habitual learning strategies following chronic stress was also identified. There was an initial reduction in acute locomotor response to methamphetamine, but no lasting effect as a result of chronic stress exposure. These findings suggest that chronic stress may facilitate the recruitment of habit- and addiction-related neurocircuitries through neuronal restructuring in the striatum.
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DOI：
10.1523/jneurosci.1809-08.2008
发表时间：
2008-10-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cano G;Mochizuki T;Saper CB
通讯作者：
Saper CB
影响因子：
4.1
作者：
HERMAN, JP;ADAMS, D;PREWITT, C
通讯作者：
PREWITT, C
影响因子：
3.3
作者：
Cruz, Fabio C.;Marin, Marcelo Tadeu;Planeta, Cleopatra S.
通讯作者：
Planeta, Cleopatra S.
影响因子：
3.4
作者：
Dilleen, Ruth;Pelloux, Yann;Belin, David
通讯作者：
Belin, David
影响因子：
4.8
作者：
Goodwin, J. Shawn;Larson, Gaynor A.;Khoshbouei, Habibeh
通讯作者：
Khoshbouei, Habibeh