Polymer chain length effects on fibroblast attachment on nylon-3-modified surfaces.
Polymer chain length effects on fibroblast attachment on nylon-3-modified surfaces.
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DOI：
10.1021/bm201847n
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发表时间：
2012-04-09
影响因子：
6.2
通讯作者：
Gellman, Samuel H.
中科院分区：
文献类型：
--
作者：
Liu, Runhui;Masters, Kristyn S.;Gellman, Samuel H.
Nylon-3聚合物在蛋白质中发现了一个聚酰胺骨架（β-氨基酸与α-氨基酸分别保留），这使得这些材料在生物学应用中变得有趣，因为环形开放的聚合过程的多功能性。疏水包括这些聚合物的阳离子亚基会导致尼龙-3表面支持细胞粘合剂和扩散的能力。修改后表面，在最佳链长度上，我们确定的最佳聚合物与含RGD的肽相媲美，以支持此处描述的成纤维细胞附着。
Nylon-3 polymers have a polyamide backbone reminiscent of that found in proteins (β- vs. α-amino acid residues, respectively), which makes these materials interesting for biological applications. Because of the versatility of the ring-opening polymerization process and the variety of β-lactam starting materials available, the structure of nylon-3 copolymers is highly amenable to alteration. A previous study showed that relatively subtle changes in the structure or ratio of hydrophobic and cationic subunits that comprise these polymers can result in significant changes in the ability of nylon-3-bearing surfaces to support cell adhesion and spreading. In the present study we have exploited the highly tailorable nature of these polymers to synthesize new versions possessing a wide range of chain lengths, with the intent of optimizing these materials for use as cell-supportive substrates. We find that longer nylon-3 chains lead to better fibroblast growth on modified surfaces, and that at the optimal chain lengths, less hydrophobic subunits are superior. The best polymers we identified are comparable to an RGD-containing peptide in supporting fibroblast attachment. The results described here will help to focus future efforts aimed at refining nylon-3 copolymer substrates for specific tissue engineering applications.
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影响因子：
14
作者：
Benton, Julie A.;Fairbanks, Benjamin D.;Anseth, Kristi S.
通讯作者：
Anseth, Kristi S.
影响因子：
15
作者：
Dohm, Michelle T.;Mowery, Brendan P.;Czyzewski, Ann M.;Stahl, Shannon S.;Gellman, Samuel H.;Barron, Annelise E.
通讯作者：
Barron, Annelise E.
影响因子：
15
作者：
Lee, Myung-Ryul;Stahl, Shannon S.;Gellman, Samuel H.;Masters, Kristyn S.
通讯作者：
Masters, Kristyn S.
DOI：
10.1002/jbm.820260704
发表时间：
1992-07-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
STEELE, JG;JOHNSON, G;UNDERWOOD, PA
通讯作者：
UNDERWOOD, PA
影响因子：
56.9
作者：
RUOSLAHTI, E;PIERSCHBACHER, MD
通讯作者：
PIERSCHBACHER, MD