Mesenchymal stem cells at the intersection of cell and gene therapy.
Mesenchymal stem cells at the intersection of cell and gene therapy.
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DOI：
10.1517/14712598.2010.531257
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发表时间：
2010-12
影响因子：
4.6
通讯作者：
Spagnoli A
中科院分区：
文献类型：
--
作者：
Myers TJ;Granero-Molto F;Longobardi L;Li T;Yan Y;Spagnoli A
间充质干细胞具有分化成成骨细胞、软骨细胞和脂肪细胞的能力。除了分化之外，间充质干细胞还可以调节炎症、受损组织的所在地并分泌生物活性分子。这些特性可以通过基因修饰来增强，结合细胞和基因治疗领域的优点来治疗单基因和多基因疾病。对证明 MSC 的免疫调节、归巢和旁分泌活性的研究结果进行了回顾，随后总结了利用 MSC 作为基因治疗载体的当前研究，重点关注骨骼疾病，但也包括心血管疾病、缺血性损伤和癌症。间充质干细胞是许多疾病的一种可能的治疗方法，特别是那些与肌肉骨骼系统相关的疾病，作为一种独立的治疗方法，或与通过抗炎和免疫调节作用、分化、血管生成、细胞溶解剂或合成代谢剂的递送增强这些细胞迁移、存活或促进愈合的能力的因子组合。转基因间充质干细胞是一个有前途的研究领域，通过关注间充质干细胞的生物学特性，可以对这一领域进行改进，从而识别天然和移植的间充质干细胞生态位，并就如何分离和扩增间充质干细胞用于治疗目的达成共识。
Mesenchymal stem cells have the ability to differentiate into osteoblasts, chondrocytes and adipocytes. Along with differentiation, MSCs can modulate inflammation, home to damaged tissues and secret bioactive molecules. These properties can be enhanced through genetic-modification that would combine the best of both cell and gene therapy fields to treat monogenic and multigenic diseases. A review of the findings demonstrating the immunomodulation, homing and paracrine activities of MSCs followed by a summary of the current research utilizing MSCs as a vector for gene therapy, focusing on skeletal disorders, but also cardiovascular disease, ischemic damage and cancer. MSCs are a possible therapeutic for many diseases, especially those related to the musculoskeletal system, as a standalone treatment, or in combination with factors that enhance the abilities of these cells to migrate, survive or promote healing through anti-inflammatory and immunomodulatory effects, differentiation, angiogenesis, delivery of cytolytic or anabolic agents. Genetically-modified MSCs are a promising area of research that would be improved by focusing on the biology of MSCs that could lead to identification of the natural and engrafting MSC-niche and a consensus on how to isolate and expand MSCs for therapeutic purposes.
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影响因子：
12.4
作者：
Chen, Xiancheng;Lin, Xiaojuan;Zhao, Xia
通讯作者：
Zhao, Xia
影响因子：
12.4
作者：
Cavarretta, Ilaria T.;Altanerova, Veronika;Altaner, Cestmir
通讯作者：
Altaner, Cestmir
影响因子：
0.7
作者：
De-Miguel, Maria P.;Arnalich-Montiel, Francisco;Nistal, Manuel
通讯作者：
Nistal, Manuel
影响因子：
56.9
作者：
Chamberlain, JR;Schwarze, U;Russell, DW
通讯作者：
Russell, DW
DOI：
10.1111/j.1749-6632.2009.04967.x
发表时间：
2009-01-01
期刊：
HEMATOPOIETIC STEM CELLS VII
影响因子：
--
作者：
Crisan, Mihaela;Chen, Chien-Wen;Peault, Bruno
通讯作者：
Peault, Bruno