Comprehensive interrogation of the cellular response to fluorescent, detonation and functionalized nanodiamonds.
Comprehensive interrogation of the cellular response to fluorescent, detonation and functionalized nanodiamonds.
复制标题
DOI：
10.1039/c4nr02570a
复制
发表时间：
2014-10-21
期刊：
影响因子：
6.7
通讯作者：
Ho D
中科院分区：
文献类型：
--
作者：
Moore L;Grobárová V;Shen H;Man HB;Míčová J;Ledvina M;Štursa J;Nesladek M;Fišerová A;Ho D
纳米金刚石（NDs）是一种多功能纳米颗粒，目前正在研究其在药物输送、生物医学成像和纳米级传感等方面的各种应用。虽然最初的研究表明这些小宝石具有生物相容性，但在合成方法和表面功能化方面存在很大的可变性，尚未进行评估。在这里，我们提出了纳米金刚石亚型和表面功能化策略阵列的细胞相容性的综合分析。这些结果表明，多种细胞类型在功能和基因表达水平上都能很好地耐受NDs。此外，ND介导的柔红霉素递送对多种细胞类型的毒性低于单独使用柔红霉素治疗，这表明ND制剂能够改善药物耐受性并降低治疗毒性。总之，本研究结果表明ND的生物相容性为继续进行临床前研究提供了有希望的基础。
Nanodiamonds (NDs) are versatile nanoparticles that are currently being investigated for a variety of applications in drug delivery, biomedical imaging and nanoscale sensing. Although initial studies indicate that these small gems are biocompatible, there is a great deal of variability in synthesis methods and surface functionalization that has yet to be evaluated. Here we present a comprehensive analysis of the cellular compatibility of an array of nanodiamond subtypes and surface functionalization strategies. These results demonstrate that NDs are well tolerated by multiple cell types at both functional and gene expression levels. In addition, ND-mediated delivery of daunorubicin is less toxic to multiple cell types than treatment with daunorubicin alone, demonstrating the ability of the ND agent to improve drug tolerance and decrease therapeutic toxicity. Overall, the results here indicate that ND biocompatibility serves as a promising foundation for continued preclinical investigation.
登录
查看更多内容
影响因子：
29.4
作者：
Moore, Laura;Chow, Edward Kai-Hua;Osawa, Eiji;Bishop, J. Michael;Ho, Dean
通讯作者：
Ho, Dean
影响因子：
3.5
作者：
Boudou, Jean-Paul;Curmi, Patrick A.;Gaffet, Eric
通讯作者：
Gaffet, Eric
影响因子：
29.4
作者：
Ozawa, Masaki;Inaguma, Masayasu;Osawa, Eiji
通讯作者：
Osawa, Eiji
影响因子：
15
作者：
Mochalin, Vadym N.;Gogotsi, Yury
通讯作者：
Gogotsi, Yury
影响因子：
17.1
作者：
Chow, Edward K.;Zhang, Xue-Qing;Ho, Dean
通讯作者：
Ho, Dean