Diamond-lipid hybrids enhance chemotherapeutic tolerance and mediate tumor regression.
Diamond-lipid hybrids enhance chemotherapeutic tolerance and mediate tumor regression.
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DOI：
10.1002/adma.201300343
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发表时间：
2013-07-12
影响因子：
29.4
通讯作者：
Ho, Dean
中科院分区：
文献类型：
--
作者：
Moore, Laura;Chow, Edward Kai-Hua;Osawa, Eiji;Bishop, J. Michael;Ho, Dean
目前肿瘤化疗的临床标准存在水溶性差、循环半衰期短、毒性大、细胞耐药等缺点。靶向纳米颗粒给药系统具有克服这些挑战的潜力[1-4]。纳米金刚石（NDs）在生物医学成像和药物传递领域显示出巨大的前景，并与各种小分子治疗剂、造影剂、蛋白质、聚合物和核酸一起功能化[1,2,5 -16]。尽管NDs既安全[2,17 -20]，又能有效输送造影剂[2,15]和化疗药物[2,9,19]，但体内肿瘤定位主要依赖于被动机制。先前的研究已经报道了通过蛋白质配体或抗体的共价附着将纳米颗粒靶向到特定细胞亚群的能力[9,21 -24]。由于这个原因，我们开发了自组装的纳米金刚石-脂质杂化颗粒（ndlp），利用纳米金刚石* dean之间的有效相互作用。ho@加州大学洛杉矶分校。edu。目前地址：新加坡国立大学药学系永禄林医学院新加坡117599
The current clinical standards in cancer chemotherapy are limited by shortcomings such as poor water solubility, short circulation half-life, high toxicity and cellular resistance. Targeted nanoparticle drug delivery systems have the potential to overcome a number of these challenges [1-4]. Nanodiamonds (NDs) have shown great promise in the fields of biomedical imaging and drug delivery and have been functionalized with a variety of small molecule therapeutics, contrast agents, proteins, polymers and nucleic acids [1, 2, 5-16]. Although NDs are both safe [2, 17-20] and effective at delivering contrast agents [2, 15] and chemotherapeutics [2, 9, 19], in vivo tumor localization has been primarily reliant on passive mechanisms. Previous studies have reported the ability to target nanoparticles to specific subpopulations of cells through the covalent attachment of a protein ligand or antibody [9, 21-24]. For this reason we have developed self-assembled nanodiamond-lipid hybrid particles (NDLPs) that harness the potent interaction between the nanodiamond* dean. ho@ ucla. edu. Chow Current Address: Cancer Science Institute of Singapore Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Singapore 117599
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影响因子：
4.2
作者：
Nogi, Hiroko;Kobayashi, Tadashi;Uchida, Ken
通讯作者：
Uchida, Ken
DOI：
10.1016/0005-2736(90)90440-y
发表时间：
1990-11-02
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
BLUME, G;CEVC, G
通讯作者：
CEVC, G
影响因子：
15
作者：
Mochalin, Vadym N.;Gogotsi, Yury
通讯作者：
Gogotsi, Yury
影响因子：
5.7
作者：
Chen, Mark;Zhang, Xue-Qing;Ho, Dean
通讯作者：
Ho, Dean
影响因子：
10.8
作者：
Mohan, Nitin;Chen, Chao-Sheng;Chang, Huan-Cheng
通讯作者：
Chang, Huan-Cheng