Glucagon-like peptide-1 (GLP-1) analogs: recent advances, new possibilities, and therapeutic implications.
Glucagon-like peptide-1 (GLP-1) analogs: recent advances, new possibilities, and therapeutic implications.
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DOI：
10.1021/jm500810s
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发表时间：
2015-02-12
影响因子：
7.3
通讯作者：
Ahn JM
中科院分区：
文献类型：
--
作者：
Manandhar B;Ahn JM
胰高血糖素样肽-1（GLP-1）是一种肠促胰岛素，在葡萄糖稳态中起重要的生理作用。它在食物摄入后从肠道产生，刺激胰岛素分泌并保持胰腺β细胞健康和增殖。由于这些有益的作用，它在过去的十年中吸引了大量的关注，并且基于肽出现了一种全新的糖尿病治疗方法。除了治疗应用外，GLP-1类似物还表现出胰腺β细胞分子成像的潜力;这可能有助于疾病的早期检测和治疗干预（包括胰岛移植）的评估。在这个角度来看，我们专注于GLP-1类似物的研究，改善生物活性，提高代谢稳定性，受体相互作用的调查，和可视化的胰岛。
Glucagon-like peptide-1 (GLP-1) is an incretin that plays important physiological roles in glucose homeostasis. Produced from intestine upon food intake, it stimulates insulin secretion and keeps pancreatic β-cells healthy and proliferating. Because of these beneficial effects, it has attracted a great deal of attention in the past decade, and an entirely new line of diabetic therapeutics has emerged based on the peptide. In addition to the therapeutic applications, GLP-1 analogs have demonstrated a potential in molecular imaging of pancreatic β-cells; this may be useful in early detection of the disease and evaluation of therapeutic interventions, including islet transplantation. In this Perspective, we focus on GLP-1 analogs for their studies on improvement of biological activities, enhancement of metabolic stability, investigation of receptor interaction, and visualization of the pancreatic islets.
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DOI：
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发表时间：
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期刊：
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影响因子：
--
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通讯作者：
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影响因子：
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DOI：
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发表时间：
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影响因子：
11.1
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