Interferon gamma enhances both in vitro and in vivo priming of CD4+ T cells for IL-4 production.
Interferon gamma enhances both in vitro and in vivo priming of CD4+ T cells for IL-4 production.
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γ 干扰素可在体外和体内增强 CD4+ T 细胞产生 IL-4 的启动作用。
DOI：
10.1084/jem.20032014
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发表时间：
2004-06-21
影响因子：
15.3
通讯作者：
Paul, WE
中科院分区：
文献类型：
--
作者：
Bocek, P;Foucras, G;Paul, WE
Classical studies have demonstrated that in vitro priming of naive CD4 T cells to become T helper (Th)2 cells is strikingly dependent on interleukin (IL)-4, whereas priming for interferon (IFN)γ production is IL-12/IFNγ-dependent. Therefore, it was quite surprising when we noted that priming of naive C57BL/6 CD4+ cells to become IL-4 producers was substantially inhibited by the addition of anti-IFNγ antibodies. This was true using immobilized anti-CD3 and anti-CD28 antibodies or soluble anti-CD3/anti-CD28 and antigen-presenting cells in the presence or absence of added IL-4. Priming of CD4 T cells from IFNγ−/− C57BL/6 mice with immobilized anti-CD3 and anti-CD28 resulted in limited production of IL-4, even with the addition of 1,000 U/ml of IL-4. Titrating IFNγ into such cultures showed a striking increase in the proportion of T cells that secreted IL-4 upon challenge; this effect was completely IL-4–dependent in that it was blocked with anti–IL-4 antibody. Thus, IFNγ plays an unanticipated but substantial role in Th2 priming, although it is an important Th1 cytokine, and under certain circumstances a Th1 inducer.
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影响因子：
6.7
作者：
Rao, A;Avni, O
通讯作者：
Avni, O
影响因子：
15.3
作者：
Szabo, SJ;Dighe, AS;Gubler, U;Murphy, KM
通讯作者：
Murphy, KM
DOI：
10.1084/jem.187.3.307
发表时间：
1998-02-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Mencacci A;Del Sero G;Cenci E;d'Ostiani CF;Bacci A;Montagnoli C;Kopf M;Romani L
通讯作者：
Romani L
影响因子：
30.5
作者：
Biedermann, T;Zimmermann, S;Röcken, M
通讯作者：
Röcken, M
DOI：
10.1073/pnas.060026497
发表时间：
2000-03-28
影响因子：
11.1
作者：
Huang, LR;Chen, FL;Kung, JT
通讯作者：
Kung, JT