High Proteoglycan Decorin Levels Are Associated With Acute Coronary Syndrome and Provoke an Imbalanced Inflammatory Response.
High Proteoglycan Decorin Levels Are Associated With Acute Coronary Syndrome and Provoke an Imbalanced Inflammatory Response.
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DOI：
10.3389/fphys.2021.746377
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发表时间：
2021
影响因子：
4
通讯作者：
Tao R
中科院分区：
文献类型：
--
作者：
Zhuang L;Ge Y;Zong X;Yang Q;Zhang R;Fan Q;Tao R
背景和目的：急性冠状动脉综合征（ACS）已成为最常见的致残原因之一。因此，重要的是使用新的生物标志物在患者的疾病过程中早期识别ACS以进行及时管理。核心蛋白聚糖（DCN）因其对胶原纤维形成和维持组织完整性的作用而被广泛认可。此外，在病理条件下，DCN可以分泌蛋白多糖的形式释放。因此，我们的目的是确定血清DCN浓度与ACS之间的关系。研究方法：本研究共纳入了388例2016年6月至2017年12月在瑞金医院心血管中心接受冠状动脉造影（CAG）的患者。采用酶联免疫吸附法测定210例ACS患者和178例对照者CAG手术期间血清DCN水平。结果如下：ACS患者血清DCN水平明显高于对照组（13.59 ± 0.50 vs.13.17 ± 0.38，P < 0.001）。此外，血清DCN水平，在调整其他心血管因素后，与ACS独立相关。此外，血清DCN水平升高与白色血细胞数和高敏C反应蛋白水平呈正相关（R分别为0.3和0.11）。从机制上讲，DCN可能通过抑制抗炎基因的表达，在心肌缺血期间引起不平衡的炎症反应。结论：血清DCN是ACS的一个新的生物标志物，并参与了缺血性心脏病炎症反应的增加。
Background and Aims: Acute coronary syndrome (ACS) has become one of the most common causes of disability. It is thus important to identify ACS early in the disease course of patients using novel biomarkers for prompt management. Decorin (DCN) was well-acknowledged for its effect on collagen fibrillogenesis and maintaining tissue integrity. Additionally, DCN could release as secreted proteoglycan under pathological conditions. Hence, we aimed to determine the relationship between serum DCN concentration and ACS. Methods: A total of 388 patients who underwent coronary angiography (CAG) in the cardiovascular center of Ruijin Hospital between June 2016 and December 2017 were enrolled in this study. Blood samples were drawn during CAG surgery to determine the serum DCN level of patients with ACS (n = 210) and control subjects (n = 178) using enzyme-linked immunosorbent assay. Results: We found that the serum DCN levels of ACS patients were elevated compared with those of the control subjects (13.59 ± 0.50 vs. 13.17 ± 0.38, respectively, p < 0.001). Furthermore, the serum DCN level, after being adjusted with other cardiovascular factors, was independently associated with ACS. Moreover, an increased serum DCN level was positively correlated with the number of white blood cells and the level of high-sensitivity C-reactive protein (R = 0.3 and 0.11, respectively). Mechanistically, DCN might have elicited an imbalanced inflammatory response during cardiac ischemia by suppressing the expression of anti-inflammatory genes. Conclusion: Serum DCN is a novel biomarker of ACS and contributes to the increased inflammatory response in ischemic heart disease.
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影响因子：
5.3
作者：
Neufeld, Edward B.;Zadrozny, Leah M.;Phillips, Darci;Aponte, Angel;Yu, Zu-Xi;Balaban, Robert S.
通讯作者：
Balaban, Robert S.
影响因子：
64.8
作者：
BORDER, WA;NOBLE, NA;RUOSLAHTI, E
通讯作者：
RUOSLAHTI, E
影响因子：
6.9
作者：
Weis, SM;Zimmerman, SD;McCulloch, AD
通讯作者：
McCulloch, AD
影响因子：
6.9
作者：
Fansson, LÅ;Belting, M;Oldberg, Å
通讯作者：
Oldberg, Å
影响因子：
2.9
作者：
Underhill, Lori A.;Avalos, Nora;Lechner, Beatrice
通讯作者：
Lechner, Beatrice