Local effect of vasoactive intestinal polypeptide on human sweat-gland function.
Local effect of vasoactive intestinal polypeptide on human sweat-gland function.
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血管活性肠多肽对人体汗腺功能的局部影响。
DOI：
10.2170/jjphysiol.37.929
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
J. Sugenoya
中科院分区：
文献类型：
--
作者：
Y. Yamashita;T. Ogawa;N. Ohnishi;R. Imamura;J. Sugenoya
血管活性肠多肽（VIP）被认为是支配汗腺的胆碱能神经元的共同递质，通过其对药物性出汗的局部作用来研究其生理意义。将VIP、氯化甲胆碱（MCH）、或VIP + MCH分别溶于0.1 ml 0.9% NaCl溶液至规定浓度，注射于前臂15 cm2的试验区中心皮内，用电容测湿法连续记录排汗率。在较冷的环境下（Ta, 23℃），VIP没有引起汗液分泌，但增加了mch诱导的出汗速率，在浓度为10(-5)g/ml时最为显著，局部皮肤温度升高最大。在热环境下（Ta, 35℃）神经阻滞麻醉区域，效果不明显且不一致，说明在被动的皮肤血管舒张状态下，VIP的促汗作用减弱。可以假设VIP在确保足够的氧气供应给功能性汗腺方面发挥作用，特别是在皮肤血管收缩张力相对较高的情况下。
Physiological significance of vasoactive intestinal polypeptide (VIP), a putative co-transmitter of the cholinergic neuron innervating sweat glands, was investigated by its local effect on drug-induced sweating. VIP, methacholine chloride (MCH), or VIP plus MCH dissolved in 0.1 ml of 0.9% NaCl solution to a specified concentration was injected intradermally at the center of a forearm test area of 15 cm2 and the sweat rate was recorded continuously by capacitance hygrometry. In a cool environment (Ta, 23 degrees C), VIP failed to cause sweat secretion, but increased the rate of MCH-induced sweating, most markedly at a concentration of 10(-5) g/ml, where the rise in local skin temperature was the greatest. On an area anesthetized by nerve block in a hot environment (Ta, 35 degrees C), the effect was less obvious and less consistent, indicating that the sweat-facilitatory effect of VIP is reduced under the condition of passive cutaneous vasodilation. It may be postulated that VIP plays a role in securing ample oxygen supply to functioning sweat glands, especially with a relatively high cutaneous vasoconstrictor tone.
囊性纤维化患者汗腺中血管活性肠肽神经支配不足。
DOI：
10.1126/science.4035357
发表时间：
1985
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Heinz-Erian,P;Dey,RD;Flux,M;Said,SI
通讯作者：
Said,SI
血管活性肠肽对狗气管上皮离子转运的影响。
DOI：
10.1152/jappl.1983.55.6.1844
发表时间：
1983
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子：
--
作者：
Nathanson,I;Widdicombe,JH;Barnes,PJ
通讯作者：
Barnes,PJ