MRS suggests multi-regional inflammation and white matter axonal damage at 11 years following perinatal HIV infection.
MRS suggests multi-regional inflammation and white matter axonal damage at 11 years following perinatal HIV infection.
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DOI：
10.1016/j.nicl.2020.102505
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Robertson FC
中科院分区：
文献类型：
--
作者：
Graham AS;Holmes MJ;Little F;Dobbels E;Cotton MF;Laughton B;van der Kouwe A;Meintjes EM;Robertson FC
灰质胆碱升高表明感染 PHIV 的儿童存在炎症。感染 PHIV 并接触过 PHIV 的儿童的白质 NAA 较低，这意味着轴突损伤。患有和未感染 PHIV 的儿童之间的多区域炎症因子有所不同。绝对代谢物浓度应与肌酸比率一起考虑。可以通过质子磁共振波谱在代谢水平上研究接受抗逆转录病毒治疗（ART）的围产期艾滋病毒（PHIV）儿童的神经系统变化。虽然之前针对儿童的研究主要集中在个体代谢变化上，但研究感兴趣区域内和跨区域的模式可以帮助识别艾滋病毒感染的代谢标志物。在这项研究中，来自 HIV 儿童早期抗逆转录病毒 (CHER) 试验的 76 名 PHIV 儿童、30 名 HIV 暴露-未感染 (HEU) 儿童和 30 名 HIV 未暴露 (HU) 儿童在 11.6 (sd = 0.3) 岁时使用 3 T Skyra 扫描仪进行了扫描。对基底神经节 (BG)、中额叶灰质 (MFGM) 和周缘白质 (PWM) 内的代谢物浓度进行量化，并使用线性回归比较 HIV 状态组之间的水平。进行因子分析和逻辑回归以确定感兴趣区域内和跨区域的 HIV 感染的代谢模式特征。在 BG 区域，我们观察到 PHIV 儿童和 HEU 儿童的代谢活动恢复，尽管之前在较小年龄时观察到了差异，这表明治疗可以有效减少 HIV 感染和暴露的影响。感染 PHIV 的儿童 MFGM 胆碱水平升高表明存在炎症。此外，我们观察到 PHIV 儿童和 HEU 儿童的 PWM 中 N-乙酰天冬氨酸 (NAA) 减少，表明可能存在轴突损伤。感染 PHIV 的儿童 PWM 肌酸水平较低，表明这可能不是 HIV 研究中有效的参考代谢物。最后，由 PWM NAA 和肌酸水平驱动的跨区域炎症因子和 PWM 轴突因子的因子评分将 11 岁时感染 PHIV 的儿童与未感染 HIV 的儿童（HEU 和 HU）区分开来。因此，尽管进行了早期治疗，但围产期 HIV 感染和暴露的影响在 11 岁时仍然可见。
Elevated gray matter choline suggests inflammation in children with PHIV. Children with PHIV and exposure have lower white matter NAA, implying axonal damage. A multi-regional inflammatory factor differs between children with and without PHIV. Absolute metabolite concentrations should be considered along with creatine ratios. The neurological changes in children living with perinatal HIV (PHIV) on antiretroviral therapy (ART) can be studied at a metabolic level through proton magnetic resonance spectroscopy. While previous studies in children have largely focused on individual metabolite changes, investigating patterns within and across regions of interest can aid in identifying metabolic markers of HIV infection. In this study 76 children with PHIV from the Children with HIV Early AntiRetroviral (CHER) trial, 30 children who were HIV-exposed-uninfected (HEU) and 30 children who were HIV-unexposed (HU), were scanned at the age of 11.6 (sd = 0.3) years using a 3 T Skyra scanner. Metabolite concentrations were quantified within the basal ganglia (BG), midfrontal gray matter (MFGM) and peritrigonal white matter (PWM), comparing levels between HIV status groups using linear regression. Factor analysis and logistic regression were performed to identify metabolic patterns characteristic of HIV infection within and across the regions of interest. In the BG region we observed restored metabolic activity in children with PHIV and children who were HEU, despite differences being previously observed at younger ages, suggesting that treatment may effectively reduce the effects of HIV infection and exposure. Elevated MFGM choline levels in children with PHIV are indicative of inflammation. Further, we observed reduced N-acetyl-aspartate (NAA) in the PWM of children with PHIV and children who were HEU, indicating possible axonal damage. Lower levels of PWM creatine in children with PHIV suggest that this may not be a valid reference metabolite in HIV studies. Finally, factor scores for a cross-regional inflammatory factor and a PWM axonal factor, driven by PWM NAA and creatine levels, distinguished children with PHIV from children without HIV (HEU and HU) at 11 years. Therefore, the effects of perinatal HIV infection and exposure continue to be seen at 11 years despite early treatment.
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影响因子：
3.6
作者：
Ackermann, Christelle;Andronikou, Savvas;Cotton, Mark
通讯作者：
Cotton, Mark
DOI：
10.1073/pnas.0804192105
发表时间：
2008-10-28
影响因子：
11.1
作者：
Joos, Beda;Fischer, Marek;Guenthard, Huldrych F.
通讯作者：
Guenthard, Huldrych F.
影响因子：
3.3
作者：
Jiang, ZG;Piggee, C;Markey, SP
通讯作者：
Markey, SP
DOI：
10.3174/ajnr.a4921
发表时间：
2016-12
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Ackermann C;Andronikou S;Saleh MG;Laughton B;Alhamud AA;van der Kouwe A;Kidd M;Cotton MF;Meintjes EM
通讯作者：
Meintjes EM
影响因子：
3
作者：
KAISER, HF
通讯作者：
KAISER, HF