Narasin inhibits tumor metastasis and growth of ERα‑positive breast cancer cells by inactivation of the TGF‑β/SMAD3 and IL‑6/STAT3 signaling pathways.
Narasin inhibits tumor metastasis and growth of ERα‑positive breast cancer cells by inactivation of the TGF‑β/SMAD3 and IL‑6/STAT3 signaling pathways.
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Narasin 通过灭活 TGF-β/SMAD3 和 IL-6/STAT3 信号通路来抑制肿瘤转移和 ERα-阳性乳腺癌细胞的生长。
DOI：
10.3892/mmr.2020.11624
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发表时间：
2020-12
影响因子：
3.4
通讯作者：
Li T
中科院分区：
文献类型：
--
作者：
Chen J;Huang X;Li N;Liu B;Ma Z;Ling J;Yang W;Li T
Treatment of human estrogen receptor (ER)-positive breast cancer (ER+ BC) using conventional chemotherapy remains a challenge and is often ineffective as a result of tumor metastasis. The present study aimed to investigate the ability of narasin, an ionophore antibiotic, to potentially inhibit tumor metastasis and growth in human ER+ BC. Narasin was found to have significant inhibitory abilities on cell proliferation, migration and invasion in ER+ BC cell lines MCF-7 and T47D compared with the triple-negative BC cell MDA-MB-231. For the in vivo studies, narasin effectively decreased the number of tumor metastasis nodules, tumor volume and weight without apparent toxicity in human MCF-7 nude mouse left ventricle injection tumor metastasis and xenograft models. Mechanistically, it demonstrated that exposure to TGF-β or IL-6 induced the expression of epithelial-mesenchymal transition (EMT) markers in ER+ BC cell lines. On the contrary, narasin dose-dependently reversed EMT by increasing the expression of E-cadherin and decreasing the expression of N-cadherin, vimentin, β-catenin and zinc finger E-box-binding homeobox 1 at the protein and gene expression levels. Gene microarray, molecular docking and western blotting were performed to demonstrate that those protein and gene expression levels are regulated by the inactivation of the TGF-β/phosphorylated (p)-SMAD3 and IL-6/p-STAT3 signaling pathways. Taken together, these findings indicated that narasin may be a promising candidate that can be further optimized for the treatment of human ER+ BC.
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影响因子：
2
作者：
Lou, Wei;Chen, Yan;Wang, Jun
通讯作者：
Wang, Jun
影响因子：
3.2
作者：
Cybulski, Wojciech;Radko, Lidia;Rzeski, Wojciech
通讯作者：
Rzeski, Wojciech
氯化两面针碱抑制 STAT3 信号通路抑制人胃癌血管生成和生长
影响因子：
5.7
作者：
Chen, Jing;Wang, Jieqiong;Liu, Mingyao
通讯作者：
Liu, Mingyao
影响因子：
9.3
作者：
Lucarelli, Philippe;Schilling, Marcel;Klingmueller, Ursula
通讯作者：
Klingmueller, Ursula
影响因子：
1.5
作者：
Kandasamy M;Reilmann R;Winkler J;Bogdahn U;Aigner L
通讯作者：
Aigner L