Fast-food-based hyper-alimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects.
Fast-food-based hyper-alimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects.
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DOI：
10.1136/gut.2007.131797
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发表时间：
2008-05
期刊：
影响因子：
24.5
通讯作者：
Fast Food Study Group
中科院分区：
文献类型：
--
作者：
Kechagias S;Ernersson A;Dahlqvist O;Lundberg P;Lindström T;Nystrom FH;Fast Food Study Group
目的：研究以快餐为主的高营养对肝酶和肝甘油三酯含量的影响。与平行对照组的前瞻性干预研究。瑞典林肯平大学医院。健康男性12例，健康女性6例，平均年龄(SD)26(6.6)岁，并设对照组。干预组受试者的目标是体重增加5%-15%，他们每天至少吃两顿快餐，目标是将常规卡路里摄入量增加一倍，同时采取为期4周的久坐不动的生活方式。用质子核磁共振波谱测定基线和干预后血清转氨酶和hTGC的周变化。干预组受试者体重从67.6kg9.1 kg增加到74.0kgp<；0.001。血清ALT从研究开始时的22.1(11.4)U/L上升到个人平均最高水平97(103U/L)(范围19.4-447U/L)。干预期间，18名受试者中有11名ALT持续高于参考限值(女性19U/L，男性30U/L)。糖类(单糖和双糖)摄入量与最大ALT/基线ALT比值相关(r = 0.62，p = 0.006)。HTGC从1.1(1.9)%上升到2.8(4.8)%，尽管这与ALT水平的升高无关。对照组的ALT水平没有变化。高营养本身可以在不到4周的时间内导致ALT显著升高。我们的研究清楚地表明，在评估ALT升高的受试者时，病史不仅应该包括饮酒问题，还应该包括最近是否发生过过量饮食的调查。
To study the effect of fast-food-based hyper-alimentation on liver enzymes and hepatic triglyceride content (HTGC). Prospective interventional study with parallel control group. University Hospital of Linköping, Sweden. 12 healthy men and six healthy women with a mean (SD) age of 26 (6.6) years and a matched control group. Subjects in the intervention group aimed for a body weight increase of 5–15% by eating at least two fast-food-based meals a day with the goal to double the regular caloric intake in combination with adoption of a sedentary lifestyle for 4 weeks. Weekly changes of serum aminotransferases and HTGC measured by proton nuclear magnetic resonance spectroscopy at baseline and after the intervention. Subjects in the intervention group increased from 67.6 (9.1) kg to 74.0 (11) kg in weight (p<0.001). Serum ALT increased from 22.1 (11.4) U/l at study start to an individual mean maximum level of 97 (103) U/l (range 19.4–447 U/l). Eleven of the 18 subjects persistently showed ALT above reference limits (women >19 U/l, men >30 U/l) during the intervention. Sugar (mono- and disaccharides) intake during week 3 correlated with the maximal ALT/baseline ALT ratio (r = 0.62, p = 0.006). HTGC increased from 1.1 (1.9)% to 2.8 (4.8)%, although this was not related to the increase in ALT levels. ALT levels were unchanged in controls. Hyper-alimentation per se can induce profound ALT elevations in less than 4 weeks. Our study clearly shows that in the evaluation of subjects with elevated ALT the medical history should include not only questions about alcohol intake but also explore whether recent excessive food intake has occurred.
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影响因子：
13.5
作者：
POWELL, EE;COOKSLEY, WGE;POWELL, LW
通讯作者：
POWELL, LW
影响因子：
13.5
作者：
Browning, JD;Szczepaniak, LS;Hobbs, HH
通讯作者：
Hobbs, HH
影响因子：
16.2
作者：
Bonora, E;Saggiani, F;Muggeo, M
通讯作者：
Muggeo, M
影响因子：
9.8
作者：
Daniel, S;Ben-Menachem, T;Blumenkehl, M
通讯作者：
Blumenkehl, M
DOI：
10.1152/ajpendo.00064.2004
发表时间：
2005-02-01
影响因子：
5.1
作者：
Szczepaniak, LS;Nurenberg, P;Dobbins, RL
通讯作者：
Dobbins, RL