The study of plant specialized metabolism: Challenges and prospects in the genomics era.
The study of plant specialized metabolism: Challenges and prospects in the genomics era.
复制标题
植物特化代谢研究：基因组学时代的挑战与展望
DOI：
10.1002/ajb2.1101
复制
发表时间：
2018
影响因子：
3
通讯作者：
Kruse LH
中科院分区：
文献类型：
--
作者：
Moghe GD ;Kruse LH
植物通过广泛的、进化上可延展的代谢途径网络产生各种各样的化合物。这些代谢物通常分为两种类型-初级代谢物和特化代谢物-大多数多样性发生在特化代谢物中（图1A）。代谢物的存在-不存在和类型在个体植物中（在组织/器官内/之间，发育阶段，整个昼夜节律周期），种群之间以及物种之间动态变化。保守地估计，每个物种具有约4.7种独特的代谢物，并且预计在整个植物界中存在超过一百万种代谢物（Afendi等人，2012).代谢物多样性的规模给植物特化代谢的研究提出了诸多挑战。首先，它带来了识别这些化合物的挑战。虽然基因组学和转录组学技术在过去十年中取得了显着进步，但代谢物结构及其化学性质的复杂性阻碍了采用标准化的检测方案。第二，特化代谢的谱系特异性（图1A）产生了识别生物合成酶和研究它们在非参考物种中进化的挑战。最后，关于单一植物和种群间化学结构多样性的生态重要性，还有很多需要了解的。在本文中，我们将更详细地讨论这些挑战和潜在机遇。
Plants produce a diverse array of compounds through an extensive, evolutionarily malleable network of metabolic pathways. These metabolites are typically classified into two types—primary and specialized—with most of the diversity occurring among specialized metabolites (Fig. 1A). Metabolite presence–absence and types vary dynamically in an individual plant (within/between tissues/organs, developmental stages, across the circadian cycle), between populations, and also between species. Conservatively, it was estimated that each species harbors~ 4.7 unique metabolites, and over a million metabolites were predicted to exist across the plant kingdom (Afendi et al., 2012).The scale of metabolite diversity raises multiple challenges for the study of plant specialized metabolism. First, it creates the challenge of identifying these compounds. While genomic and transcriptomic technologies have advanced significantly in the last decade, the complexity of metabolite structures and their chemical properties hinders adoption of standardized protocols for their detection. Second, the lineage-specific nature of specialized metabolism (Fig. 1A) creates the challenge of identifying biosynthetic enzymes and studying their evolution in non-reference species. Finally, there is still much to be understood about the ecological importance of chemical structural diversity in a single plant and across populations. In this article, we discuss these challenges and potential opportunities in more detail.
影响因子：
2.3
作者：
Horai, Hisayuki;Arita, Masanori;Nishioka, Takaaki
通讯作者：
Nishioka, Takaaki
影响因子：
4.8
作者：
Sedio, Brian E.;Echeverri, Juan C. Rojas;Wright, S. Joseph
通讯作者：
Wright, S. Joseph
特殊新陈代谢的显着的柔韧性和混杂性
DOI：
--
发表时间：
2013
期刊：
Cold Spring Harbor Symposia on Quantitative Biology
影响因子：
--
作者：
J. Noel
通讯作者：
J. Noel