The neurobiology of long COVID.

The neurobiology of long COVID.
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DOI:
10.1016/j.neuron.2022.10.006
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发表时间:
2022-11-02
期刊:
影响因子:
16.2
通讯作者:
Iwasaki A
Iwasaki A
中科院分区:
医学1区
文献类型:
--
作者:
Monje M;Iwasaki A

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持续的神经和神经精神症状影响了COVID-19后相当一部分人,是急性COVID-19后综合征(也称为长期COVID)的主要组成部分。在这里,我们回顾了关于急性后COVID-19对CNS影响的病理生物学的理解,并讨论了影响COVID-19幸存者的认知症状的可能神经生物学基础。我们提出了可能导致这种新出现的神经系统健康危机的主要机制。COVID-19后,持续的神经系统症状影响了相当一部分人,是长期COVID的主要组成部分。在这里,Monje和Iwasaki回顾了对长期COVID认知症状的神经生物学基础的理解。
Persistent neurological and neuropsychiatric symptoms affect a substantial fraction of people after COVID-19 and represent a major component of the post-acute COVID-19 syndrome, also known as long COVID. Here, we review what is understood about the pathobiology of post-acute COVID-19 impact on the CNS and discuss possible neurobiological underpinnings of the cognitive symptoms affecting COVID-19 survivors. We propose the chief mechanisms that may contribute to this emerging neurological health crisis. Persistent neurological symptoms affect a substantial fraction of people after COVID-19 and represent a major component of long COVID. Here, Monje and Iwasaki review what is understood about the neurobiological underpinnings of long COVID cognitive symptoms.
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