Supplementation of milk polar lipids to obese dams improves neurodevelopment and cognitive function in male offspring
Supplementation of milk polar lipids to obese dams improves neurodevelopment and cognitive function in male offspring
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向肥胖母鼠补充乳极性脂质可改善雄性后代的神经发育和认知功能
DOI：
10.1096/fj.202001974rrr
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发表时间：
2021-04
期刊：
影响因子：
4.8
通讯作者：
Xueying Mao
中科院分区：
文献类型：
--
作者：
Qichen Yuan;Han Gong;Min Du;Xueying Mao
牛奶含有大约4%的脂肪颗粒，其表面覆盖着极性脂类。尽管人们大量消费乳制品，但人们对食用牛奶中的极性脂类对代谢健康的生物学影响的研究还很少。母亲肥胖会导致子代神经发育障碍和认知障碍。考虑到母体营养的重要性，研究了母猪孕期和哺乳期补充极脂富集乳脂球膜(MFGM-PL)对神经发育的影响及其对子代认知的长期规划效应。雌性SD大鼠在交配前摄入8周的对照饮食(CON)或高脂饮食(HFD)以诱导肥胖。然后，雌性大鼠在孕期和哺乳期分别饲喂CON或HFD，并补充或不补充400 mg/kg体重的MFGM-PL。仔猪断奶后饲喂高脂饲料11周。在肥胖的水坝中补充MFGM-PL可以抑制水母和后代的体重增加和高胰岛素血症。肥胖母鼠出生的后代表现出神经反射发育延迟，断奶前神经发生受损，成年后认知障碍，这些都可以通过补充母亲的MFGM-PL来恢复。母鼠和子代HFD可在新生和成年仔鼠海马区诱导胰岛素抵抗和异常脑源性神经营养因子信号转导，但母鼠给予MFGM-PL后可恢复。本研究表明，母体补充MFGM-PL可以促进神经发育，并通过减轻海马胰岛素抵抗而对HFD所致的子代认知损害起到长期的作用。因此，MFGM-PL是一种很有前途的成分，可以对后代的大脑健康发挥有益的编程效应。
Milk contains about 4% fat globules with its surface covered by polar lipids. Despite the abundant consumption of dairy products, the biological effects of dietary milk polar lipids on metabolic health have only been sparsely examined. Maternal obesity results in neurodevelopmental disorders and cognitive impairment in offspring. Considering the importance of maternal nutrition, the effects of polar lipids‐enriched milk fat globule membrane (MFGM‐PL) supplementation to dams during pregnancy and lactation on neurodevelopment and its long‐term programming effects on offspring cognition were examined. Female Sprague‐Dawley rats consumed 8‐week control diet (CON) or high‐fat diet (HFD) to induce obesity before mating. Then, female rats were fed CON or HFD with or without the supplementation of 400 mg/kg body weight MFGM‐PL during pregnancy and lactation. The offspring were fed 11‐week HFD after weaning. MFGM‐PL supplementation to obese dams suppressed body weight gain and hyperinsulinemia in both dams and offspring. Offspring born to obese dams displayed delayed neurological reflexes development, impaired neurogenesis before weaning, and cognitive impairment in adulthood, which were recovered by maternal MFGM‐PL supplementation. Insulin resistance and aberrant brain‐derived neurotrophic factor signaling were induced in the hippocampus of neonatal and adult offspring due to maternal and progeny HFD, but recovered by maternal MFGM‐PL administration. This study demonstrates that maternal MFGM‐PL supplementation can promote neurodevelopment and exert long‐term effects against HFD‐induced cognitive impairment in offspring via alleviating hippocampal insulin resistance. Hence, MFGM‐PL is a promising ingredient for exerting beneficial programming effects on the brain health of offspring.
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孕前母亲肥胖小鼠模型与后代暴露于高脂肪饮食导致雄性后代认知障碍
影响因子：
3.7
作者：
Zhu Chen;Han Ting-Li;Zhao Yalan;Zhou Xiaobo;Mao Xun;Qi Hongbo;Baker Philip N.;Zhang Hua
通讯作者：
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DOI：
10.1113/jp273478
发表时间：
2017-03
期刊：
The Journal of Physiology
影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/j.bbi.2016.08.005
发表时间：
2016-11
期刊：
Brain, behavior, and immunity
影响因子：
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作者：
Graf AE;Lallier SW;Waidyaratne G;Thompson MD;Tipple TE;Hester ME;Trask AJ;Rogers LK
通讯作者：
Rogers LK
影响因子：
6.1
作者：
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通讯作者：
Bruce-Keller AJ
影响因子：
5.1
作者：
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通讯作者：
João Tomé-Carneiro;M. C. Crespo;E. Burgos-Ramos;C. Tomás-Zapico;A. Garcia-Serrano;Pilar Castro-Gómez;C. Venero;Inmaculada Pereda-Pérez;Inmaculada Pereda-Pérez;Shishir Baliyan;Azucena Valencia;J. Fontecha;A. Dávalos;F. Visioli;F. Visioli