Multi-echo length and offset VARied saturation (MeLOVARS) method for improved CEST imaging.
Multi-echo length and offset VARied saturation (MeLOVARS) method for improved CEST imaging.
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DOI：
10.1002/mrm.25567
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发表时间：
2015-02
影响因子：
3.3
通讯作者：
McMahon, Michael T.
中科院分区：
文献类型：
--
作者：
Song, Xiaolei;Xu, Jiadi;Xia, Shuli;Yadav, Nirbhay N.;Lal, Bachchu;Laterra, John;Bulte, Jeff W. M.;van Zijl, Peter C. M.;McMahon, Michael T.
关键词：
To develop a technique for rapid collection of CEST images with the saturation varied to modulate signal loss transfer and enhance contrast. MeLOVARS divides the saturation pulse of length Tsat into N = 3-8 submodules, each consisting of a saturation pulse with length of Tsat/N (~0.3-1 s), one or more low flip-angle gradient-echo readout(s) and a flip back pulse. This results in N readouts with increasing saturation time from Tsat/N to Tsat without extra scan time. For phantoms, 8 images with Tsat incremented every 0.5s from 0.5-4 s were collected simultaneously using MeLOVARS, which allows rapid determination of exchange rates for agent protons. For live mice bearing glioblastomas, the Z-spectra for 5 different Tsat values from 0.5-2.5 s were acquired in a time normally used for one Tsat. With the additional Tsat-dependence information, LOVARS phase maps were produced with a more clearly defined tumor boundary and an estimated 4.3-fold enhanced CNR. We also show that enhancing CNR is achievable by simply averaging the collected images or transforming them using the Principal Component Analysis (PCA). MeLOVARS enables collection of multiple saturation-time-weighted images without extra time, producing a LOVARS phase map with increased CNR.
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影响因子：
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作者：
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通讯作者：
van Zijl, Peter C. M.