Chemical and Biological Activity Profiling of Hedyosmum strigosum Todzia Essential Oil, an Aromatic Native Shrub from Southern Ecuador.
Chemical and Biological Activity Profiling of Hedyosmum strigosum Todzia Essential Oil, an Aromatic Native Shrub from Southern Ecuador.
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DOI：
10.3390/plants11212832
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发表时间：
2022-10-25
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本研究旨在测定海地草挥发油的化学成分、对映体分布和生物学特性。用波谱法测定了其抗氧化性能和抗胆碱酯酶作用，并对8种细菌和2种真菌进行了抑菌效果评价。H. strigosum是一种原生灌木，主要分布于海拔2000 ~ 3500 m的厄瓜多尔和哥伦比亚。化学成分采用GC-MS和GC-FID测定。共检测到44种化合物，占EO组成的92%以上。主要化合物为百里香酚（24.35、22.48%）、α-茶香烯（12.15、13.93%）、乙酸百里香酚（6.59、9.39%）和芳樟醇（8.73、5.82%），占总化学成分的51%以上。对映体选择分析显示有5个纯对映体，3个为外消旋混合物。ABTS实验表明，EO具有较强的抗氧化能力，SC50为25.53µg/mL，对空肠弯曲杆菌具有较强的特异性抗菌作用，MIC值为125µg/mL。对乙酰胆碱酯酶有中等抑制作用，IC50值为137.6µg/mL。据我们所知，这是第一次报道海蛞蝓的化学成分和生物学特征。
The present study aimed to determine the chemical composition, enantiomeric distribution and the biological profile of Hedyosmum strigosum essential oil (EO). The antioxidant properties and anticholinesterase effect were measured by spectroscopic methods and antimicrobial potency assessed against 8 bacteria and two fungi. H. strigosum is a native shrub, particularly found in Ecuador and Colombia at 2000 to 3500 m a.s.l. Chemical composition was determined by GC-MS and GC-FID. A total of 44 compounds were detected, representing more than 92% of the EO composition. The main compounds were thymol (24.35, 22.48%), α-phellandrene (12.15, 13.93%), thymol acetate (6.59, 9.39%) and linalool (8.73, 5.82%), accounting for more than 51% of the EO. The enantioselective analysis revealed the presence of 5 pure enantiomers and 3 more as a racemic mixture. The EO exerted a strong antioxidant capacity, determined by ABTS assay, with a SC50 of 25.53 µg/mL and a strong and specific antimicrobial effect against Campylobacter jejuni with a MIC value of 125 µg/mL. A moderate acetylcholinesterase inhibitory effect was also observed with an IC50 value of 137.6 µg/mL. To the best of our knowledge this is the first report of the chemical composition and biological profile of H. strigosum EO.
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影响因子：
2.9
作者：
Herrera, Claudia;Morocho, Vladimir;Gilardoni, Gianluca
通讯作者：
Gilardoni, Gianluca
影响因子：
2.6
作者：
Lorenzo, D;Loayza, I;Dellacassa, E
通讯作者：
Dellacassa, E
DOI：
10.3390/molecules26102949
发表时间：
2021-05-15
期刊：
Molecules (Basel, Switzerland)
影响因子：
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作者：
Burneo JI;Benítez Á;Calva J;Velastegui P;Morocho V
通讯作者：
Morocho V
影响因子：
3.7
作者：
通讯作者：
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DOI：
10.3390/molecules27123793
发表时间：
2022-06-13
期刊：
Molecules (Basel, Switzerland)
影响因子：
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