Mammalian aging driven by transcription going awry.

Mammalian aging driven by transcription going awry.
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转录出错导致哺乳动物衰老。

DOI:
10.1016/j.tig.2023.06.006
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发表时间:
2023
期刊:
Trends in genetics : TIG
影响因子:
--
通讯作者:
Dang,Weiwei
Dang,Weiwei
中科院分区:
--
文献类型:
--
作者:
McCauley,BrennaS;Dang,Weiwei

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The mechanisms that underlie increased cryptic transcription during senescence and aging have been poorly understood. Sen et al. recently identified cryptic transcription start sites (cTSSs) and chromatin state changes that may contribute to cTSS activation in mammals. Their results indicate that enhancer–promoter conversion may drive cryptic transcription in senescence.
染色质松弛和转录失调:哺乳动物衰老过程中神秘转录的视角。
DOI: 10.1093/bfgp/elab026
发表时间: 2022
影响因子: 4
作者:
McCauley,BrennaS;Dang,Weiwei
通讯作者: Dang,Weiwei
DOI: 10.1016/j.molcel.2016.05.013
发表时间: 2016-06-02
期刊: Molecular cell
影响因子: 16
作者:
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通讯作者: Brunet A