Influence of iron on microcin 25 production.
Influence of iron on microcin 25 production.
复制标题
铁对小菌素 25 生产的影响。
作者：
R. Salomón;R. Farías
研究了培养基中铁含量对肽抗生素微菌素25产量的影响;在基本培养基中合成最佳，并通过添加铁减少。大肠杆菌AY 25，抗生素的野生型生产者，表现出95%的微菌素产量下降时，在基本培养基中含有10微M铁（高铁）相比，0.2微M（低铁）。添加螯合剂的Luria肉汤引起微菌素的生产，并有一个完全逆转的螯合剂的效果，通过添加铁。对大肠杆菌铁调节蛋白（Fur）缺陷突变体的研究表明，Fur以外的其他因素也可以介导铁对微球蛋白合成的调节。
The effect of the iron content of the medium on the yield of the peptide antibiotic microcin 25 was examined; synthesis was optimal in minimal media and was reduced by adding iron. Escherichia coli AY25, the wild-type producer of the antibiotic, showed a 95% decrease in microcin yield when grown in minimal medium containing 10 microM iron (high iron) as compared to 0.2 microM (low iron). Addition of chelators to Luria broth elicited microcin production, and there was a complete reversal of the effect of the chelators by adding iron. Studies with Escherichia coli mutants deficient in iron-regulated proteins (fur) suggested that factors other than Fur could mediate iron regulation of microcin synthesis.
铁限制对大肠杆菌需氧和厌氧电子传递途径基因表达的影响。
影响因子：
2.1
作者：
Cotter,PA;Darie,S;Gunsalus,RP
通讯作者：
Gunsalus,RP