Upregulation Mitochondrial Carrier 1 (MTCH1) Is Associated with Cell Proliferation, Invasion, and Migration of Liver Hepatocellular Carcinoma.
Upregulation Mitochondrial Carrier 1 (MTCH1) Is Associated with Cell Proliferation, Invasion, and Migration of Liver Hepatocellular Carcinoma.
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DOI：
10.1155/2021/9911784
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发表时间：
2021
影响因子：
--
通讯作者：
Yuan D
中科院分区：
文献类型：
--
作者：
Chen G;Mo S;Yuan D
在全球癌症相关死亡的主要原因中，肝细胞癌（LIHC）排名第三。LIHC被定义为第六大最常诊断的癌症。线粒体载体1 （MTCH1）基因是一种蛋白质编码基因。最近的研究表明，MTCH1可能与某些疾病有关。在此，我们的研究试图探讨MTCH1在LIHC中的作用和意义。使用Kaplan Meier Plotter和GEPIA（基因表达谱交互分析）数据库来确定LIHC患者MTCH1的表达及其与预后状况的相关性。我们的研究结果首次表明，MTCH1在人类泛癌中异常表达，在LIHC中高表达。它的高表达与肿瘤的转移、分期及患者的生存不良密切相关。然后通过富集分析，发现MTCH1与LIHC中的RNA剪接密切相关。随后，我们进行了一系列功能实验。PCR数据显示，LIHC细胞株和样本均高表达MTCH1。CCK-8（细胞计数试剂盒-8）检测和Transwell检测表明，沉默MTCH1确实抑制了细胞的增殖、迁移和侵袭。这些发现提示MTCH1可作为LIHC的潜在预后生物标志物，并有望成为LIHC的治疗靶点。
Among the primary causes of cancer-associated death in the world, liver hepatocellular carcinoma (LIHC) ranks the third. LIHC is defined as the sixth most frequently diagnosed carcinoma. The gene mitochondrial carrier 1 (MTCH1) is a protein-coding gene. Recent research suggests that MTCH1 may be associated with some diseases. Here, our study attempts to explore the role and implication of MTCH1 in LIHC. Kaplan Meier Plotter and GEPIA (Gene Expression Profiling Interactive Analysis) databases were employed to determine the expression of MTCH1 and its correlation with prognostic status in LIHC patients. For the first time, our results suggested that MTCH1 was aberrantly expressed in human pan-cancer and highly expressed in LIHC. Its high expression was closely associated with metastasis of tumor, stage of cancer, and poor survival of patients. Then, through enrichment analysis, MTCH1 was found to be closely related to RNA splicing in LIHC. Subsequently, we conducted a series of functional experiments. PCR data showed that LIHC cell lines and samples are highly expressed MTCH1. CCK-8 (Cell Counting Kit-8) assays and Transwell assays indicated that silencing MTCH1 certainly suppressed cell proliferation, migration, and invasion. These findings shed the clue that MTCH1 could be regarded as the potential prognosis biomarker of LIHC and a promising therapeutic target for LIHC.
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