Free choice shapes normalized value signals in medial orbitofrontal cortex.
Free choice shapes normalized value signals in medial orbitofrontal cortex.
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DOI：
10.1038/s41467-017-02614-w
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发表时间：
2018-01-11
影响因子：
16.6
通讯作者：
Glimcher PW
中科院分区：
文献类型：
--
作者：
Yamada H;Louie K;Tymula A;Glimcher PW
Normalization is a common cortical computation widely observed in sensory perception, but its importance in perception of reward value and decision making remains largely unknown. We examined (1) whether normalized value signals occur in the orbitofrontal cortex (OFC) and (2) whether changes in behavioral task context influence the normalized representation of value. We record medial OFC (mOFC) single neuron activity in awake-behaving monkeys during a reward-guided lottery task. mOFC neurons signal the relative values of options via a divisive normalization function when animals freely choose between alternatives. The normalization model, however, performed poorly in a variant of the task where only one of the two possible choice options yields a reward and the other was certain not to yield a reward (so called: “forced choice”). The existence of such context-specific value normalization may suggest that the mOFC contributes valuation signals critical for economic decision making when meaningful alternative options are available. Neurons in prefrontal areas including the medial orbitofrontal cortex (mOFC) represent the relative reward value of choices. Here the authors report that mOFC neurons implement divisive normalization to encode the relative values of lottery options only when the decision involves free choice.
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影响因子：
9.2
作者：
Goense, Jozien B. M.;Logothetis, Nikos K.
通讯作者：
Logothetis, Nikos K.
影响因子：
5.3
作者：
Lim, Seung-Lark;O'Doherty, John P.;Rangel, Antonio
通讯作者：
Rangel, Antonio
影响因子：
2.7
作者：
Corrado, GS;Sugrue, LP;Newsome, WT
通讯作者：
Newsome, WT
影响因子：
6.1
作者：
KAHNEMAN, D;TVERSKY, A
通讯作者：
TVERSKY, A
DOI：
10.1523/jneurosci.3214-10.2011
发表时间：
2011-01-05
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Levy I;Lazzaro SC;Rutledge RB;Glimcher PW
通讯作者：
Glimcher PW