Ha-ras-1 restriction fragment length polymorphism and susceptibility to colon adenocarcinoma.
Ha-ras-1 restriction fragment length polymorphism and susceptibility to colon adenocarcinoma.
复制标题
Ha-ras-1 限制性片段长度多态性与结肠腺癌的易感性。
DOI：
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发表时间：
1987
影响因子：
8.8
通讯作者：
M. Boiocchi
中科院分区：
文献类型：
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作者：
Luca Ceccherini;V. D. Re;Alessandra Viel;G. Molaro;L. Zilli;C. Clemente;M. Boiocchi
目前尚不清楚Ha-ras-1基因的某些多态性变体是否赋予癌症的遗传易感性。然而，最近关于骨髓增生异常和肺癌的数据存在争议。为了阐明这一点，我们检测了62例结直肠腺癌患者的Ha-ras-1基因限制性片段长度多态性，并与108例健康献血员的结果进行了比较。没有检测到与癌症患者特异性相关的Ha-ras-1多态性变体。然而，一个特定的基因型是显着更频繁的健康捐赠者比癌症患者（16%对5%），这表明该基因的两个等位基因之间的相互作用。
It is not yet clear whether some polymorphic variants of the Ha-ras-1 gene confer genetic predisposition to cancer. However, recent data on myelodysplasia and lung cancer are controversial. To clarify this point, 62 colorectal adenocarcinoma patients were examined for the Ha-ras-1 gene restriction fragment length polymorphism and results were compared with those of 108 healthy blood donors. No Ha-ras-1 polymorphic variants specifically associated with the cancer patients were detected. However, a specific genotype was significantly more frequent in the healthy donors than in the cancer patients (16% versus 5%), suggesting an interaction between the two alleles of the gene.
影响因子：
56.9
作者：
SLAMON, DJ;DEKERNION, JB;CLINE, MJ
通讯作者：
CLINE, MJ