Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents.
Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents.
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DOI：
10.1111/j.2047-6310.2012.00087.x
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发表时间：
2013-02
影响因子：
3.8
通讯作者：
Fleischman A
中科院分区：
文献类型：
--
作者：
McCormack SE;Shaham O;McCarthy MA;Deik AA;Wang TJ;Gerszten RE;Clish CB;Mootha VK;Grinspoon SK;Fleischman A
Branched-chain amino acid (BCAA) concentrations are elevated in response to overnutrition, and can affect both insulin sensitivity and secretion. Alterations in their metabolism may therefore play a role in the early pathogenesis of type 2 diabetes in overweight children. To determine whether pediatric obesity is associated with elevations in fasting circulating concentrations of branched-chain amino acids (isoleucine, leucine, and valine), and whether these elevations predict future insulin resistance. Sixty-nine healthy subjects, ages 8 to18 years, were enrolled as a cross-sectional cohort. A subset who were pre- or early-pubertal, ages 8 to 13 years, were enrolled in a prospective longitudinal cohort for 18 months (n=17 with complete data). Elevations in the concentrations of BCAA’s were significantly associated with BMI Z-score (Spearman’s Rho 0.27, p=0.03) in the cross-sectional cohort. In the subset of subjects followed longitudinally, baseline BCAA concentrations were positively associated with HOMA-IR measured 18 months later after controlling for baseline clinical factors including BMI Z-score, sex, and pubertal stage (p=0.046). Elevations in the concentrations of circulating branched-chain amino acids are significantly associated with obesity in children and adolescents, and may independently predict future insulin resistance.
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影响因子：
3.7
作者：
Macotela Y;Emanuelli B;Bång AM;Espinoza DO;Boucher J;Beebe K;Gall W;Kahn CR
通讯作者：
Kahn CR
影响因子：
9.8
作者：
MOTIL, KJ;BIER, DM;YOUNG, VR
通讯作者：
YOUNG, VR
影响因子：
7.7
作者：
Krebs, M;Krssak, M;Roden, M
通讯作者：
Roden, M
影响因子：
4.9
作者：
Gruber, H-J;Mayer, C.;Wilders-Truschnig, M.
通讯作者：
Wilders-Truschnig, M.
影响因子：
9.8
作者：
CABALLERO, B;WURTMAN, RJ
通讯作者：
WURTMAN, RJ