Potential Roles of O-GlcNAcylation in Primary Cilia- Mediated Energy Metabolism.
Potential Roles of O-GlcNAcylation in Primary Cilia- Mediated Energy Metabolism.
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DOI：
10.3390/biom10111504
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发表时间：
2020-11-01
期刊：
影响因子：
5.5
通讯作者：
Gomeshtapeh FI
中科院分区：
文献类型：
--
作者：
Tian JL;Gomeshtapeh FI
初级纤毛是真核细胞上的一种触角状结构，其功能是通过沿着分布于纤毛膜上的受体和离子通道将细胞外信号转化为细胞内信号。这种细胞器的功能障碍导致一系列人类疾病，称为纤毛病，通常以肥胖和糖尿病为特征;这表明初级纤毛在能量代谢中的积极作用，它主要通过下丘脑神经元，前脂肪细胞和胰腺β细胞进行控制。营养传感器O-GlcNAc广泛参与能量稳态的调节。O-GlcNAc不仅调节纤毛长度，而且还修饰纤毛介导的代谢信号通路的许多组分。因此，O-GlcNAc酰化（OGN）可能在调节初级纤毛的能量稳态中起重要作用。异常OGN，如在肥胖和糖尿病的情况下所见，可能在这些病理介导的原发性纤毛功能障碍中起重要作用。
The primary cilium, an antenna-like structure on most eukaryotic cells, functions in transducing extracellular signals into intracellular responses via the receptors and ion channels distributed along it membrane. Dysfunction of this organelle causes an array of human diseases, known as ciliopathies, that often feature obesity and diabetes; this indicates the primary cilia’s active role in energy metabolism, which it controls mainly through hypothalamic neurons, preadipocytes, and pancreatic β-cells. The nutrient sensor, O-GlcNAc, is widely involved in the regulation of energy homeostasis. Not only does O-GlcNAc regulate ciliary length, but it also modifies many components of cilia-mediated metabolic signaling pathways. Therefore, it is likely that O-GlcNAcylation (OGN) plays an important role in regulating energy homeostasis in primary cilia. Abnormal OGN, as seen in cases of obesity and diabetes, may play an important role in primary cilia dysfunction mediated by these pathologies.
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