Pristane cadmium chloride nanoemulsion accelerates the onset of systemic lupus erythematosus in a C57BL/6 mouse model
Pristane cadmium chloride nanoemulsion accelerates the onset of systemic lupus erythematosus in a C57BL/6 mouse model
复制标题
降植烷氯化镉纳米乳加速 C57BL/6 小鼠模型中系统性红斑狼疮的发病
作者：
Yi;Suhai Qian;Shate Xiang;Jingjing Zhang;Meng Zhang;Xing
Objective To accelerate the onset of systemic lupus erythematosus in C57BL/6 mice by injecting cadmium chloride nanoemulsion and shorten the traditional modeling time. Methods Pristane cadmium chloride nanoemulsion was prepared, and 66 C57BL/6 mice were randomly divided into four groups. The pristane group was intraperitoneally injected with 0.6 mL of pristane blank nanoemulsion, the model group was injected with 0.6 mL of pristane cadmium chloride nanoemulsion, the Cadmium chloride control group was injected with 0.6 mL of cadmium chloride nanoemulsion, and the control group was injected with the same amount of 0.9% sodium chloride solution. Urine protein content, anti-dsDNA antibody content, Th1 cell/Th2 cell ratio, and kidney staining were detected in each group. Results The model group began to develop disease in the 4th week, the anti-dsDNA antibody level reached 566.71 ± 1.44 ng/L, and the proteinuria reached 245.38 ± 30.54 ng/mL. The model group showed an onset at least 5 weeks earlier than that in the pristane group. There was no significant difference in anti-dsDNA antibody content between Cadmium chloride control group and blank group. At the 12th week, the Th1/Th2 cell ratio in the model group significantly decreased, and the pathological changes in the kidneys were consistent with the typical manifestations of lupus in mouse models. Conclusion These results suggest that cadmium chloride promotes earlier onset of pristane-induced systemic lupus erythematosus in a C57BL/6 mouse model.
登录
查看更多内容
影响因子：
--
作者：
MCCARTY, DJ;MANZI, S;KWOH, CK
通讯作者：
KWOH, CK
影响因子：
--
作者：
A. Stoica;B. Katzenellenbogen;M. Martin
通讯作者：
A. Stoica;B. Katzenellenbogen;M. Martin
DOI：
10.1073/pnas.92.24.10934
发表时间：
1995-11-21
影响因子：
11.1
作者：
SATOH, M;KUMAR, A;REEVES, WH
通讯作者：
REEVES, WH
影响因子：
8.8
作者：
Laursen, M L
通讯作者：
Laursen, M L