Seizure Adequacy Markers and the Prediction of Electroconvulsive Therapy Response
Seizure Adequacy Markers and the Prediction of Electroconvulsive Therapy Response
复制标题
癫痫充分性标记和电惊厥治疗反应的预测
作者：
A. Minelli;M. Abate;E. Zampieri;G. Gainelli;L. Trabucchi;M. Segala;R. Sartori;M. Gennarelli;A. Conca;M. Bortolomasi
目的电休克治疗（ECT）是治疗难治性抑郁症最有效的方法，但部分患者在短时间内无反应或复发。电休克治疗刺激参数可能与结局相关。我们进行了一项回顾性研究，以调查各种ECT参数的结果，临床变量和药物治疗。我们的目的是了解哪些因素可以被认为是假定的癫痫发作质量标志物，哪些与临床实践相关。方法采用双盲法对45例接受ECT治疗的难治性抑郁症患者进行癫痫发作持续时间、发作后抑制指数、波幅、心动过速、半球脑电波同步性等指标的评估。结果分析显示，结果与参数测量的ECT癫痫发作质量之间存在显著相关性（P = 9.9 × 10−5）。在癫痫发作质量差的患者中，61.5%在最后一次ECT治疗后约1个月复发。特别是，更高的脑电活动降低与半球脑波同步性的更高质量（P = 5.0 × 10−6）以及更高的波幅（P = 0.01）之间存在关联。结论ECT患者癫痫发作质量与抑郁性精神障碍发生率的降低密切相关。
Objectives Electroconvulsive therapy (ECT) is the most effective therapy for patients with treatment-resistant depression; however, some patients do not respond or relapse in a short time. Electroconvulsive therapy stimulus parameters may be related to the outcome. We carried out a retrospective study review to investigate various ECT parameters in relation to the outcome, clinical variables, and pharmacological treatments. Our aim was to understand which factors could be considered putative seizure quality markers and which are relevant to clinical practice. Methods Two physicians evaluated the seizure length, the postictal suppression index, the wave amplitude, tachycardia, and hemispheric brain wave synchronicity in a double-blind manner for 45 treatment-resistant depression patients receiving ECT. Results The analysis showed a significant association between the outcome and the ECT seizure quality measured by the parameters (P = 9.9 × 10−5). Among patients with poor-quality seizures, 61.5% relapsed after approximately 1 month from the last ECT session. Particularly, there was an association between higher symptomatology decrease and higher quality of hemispheric brain wave synchronicity (P = 5.0 × 10−6), as well as a higher wave amplitude (P = 0.01). Conclusions Our results confirm that ECT seizure quality was strongly correlated with the decrease of depressive symptomatology.
DOI：
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发表时间：
1997-05
期刊：
The Journal of clinical psychiatry
影响因子：
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作者：
M. Thase;A. Rush
通讯作者：
M. Thase;A. Rush
DOI：
10.1097/yct.0000000000000121
发表时间：
2014-06
期刊：
The journal of ECT
影响因子：
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作者：
McCall WV;Andrade C;Sienaert P
通讯作者：
Sienaert P