Transgenic mice: What are we learning about gene function and neurological disease?
Transgenic mice: What are we learning about gene function and neurological disease?
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转基因小鼠：我们对基因功能和神经系统疾病了解多少？
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
F. Longo
中科院分区：
文献类型：
--
作者：
F. Longo
日期。在这一点上，我们只能推测，影响细胞间相互作用和信号转导的基因数量过多可能反映了胚胎存活不一定需要的功能，但可能对神经系统发育或生理学特别重要。由于发现了导致大多数早发家族性阿尔茨海默病和亨廷顿病等三核苷酸重复疾病的功能未知的基因，因此破译基因功能的重要性尤其突出。许多疾病基因中缺乏可识别的序列基序表明新的功能类别尚未被发现。对于三核苷酸重复基因，
dated. At this point, one can only speculate that the disproportionate number of genes affecting cell-cell interaction and signal transduction might be a reflection of functions not necessarily required for embryonic survival but might be especially critical to nervous system development or physiology. The importance of deciphering gene function has been especially highlighted by the discovery of the genes without known functions causing the majority of early onset familial Alzheimer’s disease and trinucleotide repeat diseases such as Huntington’s disease. The lack of recognizable sequence motifs in many disease genes suggests that new functional categories are yet to be discovered. In the case of trinucleotide repeat genes,
影响因子：
56.9
作者：
THREADGILL, DW;DLUGOSZ, AA;MAGNUSON, T
通讯作者：
MAGNUSON, T
影响因子：
10.5
作者：
BRANNAN, CI;PERKINS, AS;COPELAND, NG
通讯作者：
COPELAND, NG