Effect of systemically administered oxytocin on dose response for methylphenidate self-administration and mesolimbic dopamine levels.
Effect of systemically administered oxytocin on dose response for methylphenidate self-administration and mesolimbic dopamine levels.
复制标题
DOI：
10.1111/nyas.14101
复制
发表时间：
2019-11
影响因子：
5.2
通讯作者：
Tanda, Gianluigi
中科院分区：
文献类型：
--
作者：
Lee, Mary R.;Rohn, Matthew C. H.;Zanettini, Claudio;Coggiano, Mark A.;Leggio, Lorenzo;Tanda, Gianluigi
The neuropeptide oxytocin (OT) alters behaviors related to the administration of drugs of abuse, including stimulants. OT also plays a key role in social bonding, which involves an interaction between OT and dopamine (DA) in the nucleus accumbens (NAc). The nature of the interaction between OT and DA in the striatum in the context of psychostimulants is unclear. We investigated the effect of OT, delivered intraperitoneally, on the methylphenidate (MP) dose–response function in rats. Food was used as a control condition. In a microdialysis study, we measured the effect of intraperitoneal OT on MP-stimulated striatal DA levels. Systemic OT pretreatment caused a downward shift in the MP dose–response function while having no effect on motor activity. OT also caused a reduction in food self-administration, although a significantly higher dose of OT was required for this effect compared to that required for a reduction of MP self-administration. Systemic OT pretreatment caused a potentiation of MP-stimulated DA levels in the NAc shell but not in the core. The significance of these findings is discussed, including the potential of OT as a therapeutic agent for addictive disorders.
登录
查看更多内容
DOI：
10.1523/jneurosci.6588-10.2011
发表时间：
2011-04-20
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ito R;Hayen A
通讯作者：
Hayen A
影响因子：
10.6
作者：
Cox BM;Bentzley BS;Regen-Tuero H;See RE;Reichel CM;Aston-Jones G
通讯作者：
Aston-Jones G
影响因子：
10.6
作者：
Kohut SJ;Hiranita T;Hong SK;Ebbs AL;Tronci V;Green J;Garcés-Ramírez L;Chun LE;Mereu M;Newman AH;Katz JL;Tanda G
通讯作者：
Tanda G
DOI：
10.1073/pnas.0911998107
发表时间：
2010-01-19
影响因子：
11.1
作者：
Liu, Yan;Aragona, Brandon J.;Wang, Zuoxin
通讯作者：
Wang, Zuoxin
影响因子：
10.6
作者：
Garces-Ramirez, Linda;Green, Jennifer L.;Hiranita, Takato;Kopajtic, Theresa A.;Mereu, Maddalena;Thomas, Alexandra M.;Mesangeau, Christophe;Narayanan, Sanju;McCurdy, Christopher R.;Katz, Jonathan L.;Tanda, Gianluigi
通讯作者：
Tanda, Gianluigi