Adenovirus receptors and their implications in gene delivery.
Adenovirus receptors and their implications in gene delivery.
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DOI：
10.1016/j.virusres.2009.02.010
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发表时间：
2009-08
期刊：
影响因子：
5
通讯作者：
Mittal, Suresh K.
中科院分区：
文献类型：
--
作者：
Sharma, Anurag;Li, Xiaoxin;Bangari, Dinesh S.;Mittal, Suresh K.
腺病毒(Ads)作为基因递送载体在治疗和预防中的应用日益广泛。AD进入宿主细胞涉及细胞表面受体和病毒衣壳蛋白之间的特定相互作用。一些细胞表面分子已被确定为Ad附着和进入的受体。腺病毒载体的组织趋向性受其受体使用的影响很大。人们已经研究了多种策略来通过操纵受体相互作用部分来改变Ad载体的趋向性。许多这样的策略旨在对准和/或去对准广告载体。在这篇综述中，我们讨论了作为病毒附着和内化的受体的各种细胞表面分子。特别强调了作为基因递送载体的广告类型。还讨论了利用Ad受体的知识来改变Ad趋向性的各种策略。
Adenoviruses (Ads) have gained popularity as gene delivery vectors for therapeutic and prophylactic applications. Ad entry into host cells involves specific interactions between cell surface receptors and viral capsid proteins. Several cell surface molecules have been identified as receptors for Ad attachment and entry. Tissue tropism of Ad vectors is greatly influenced by their receptor usage. A variety of strategies have been investigated to modify Ad vector tropism by manipulating the receptor-interacting moieties. Many such strategies are aimed at targeting and/or detargeting of Ad vectors. In this review, we discuss the various cell surface molecules that are implicated as receptors for virus attachment and internalization. Special emphasis is given to Ad types that are utilized as gene delivery vectors. Various strategies to modify Ad tropism using the knowledge of Ad receptors are also discussed.
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