Development of nonhuman adenoviruses as vaccine vectors.
Development of nonhuman adenoviruses as vaccine vectors.
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DOI：
10.1016/j.vaccine.2005.08.101
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发表时间：
2006-02-13
期刊：
影响因子：
5.5
通讯作者：
Mittal, SK
中科院分区：
文献类型：
--
作者：
Bangari, DS;Mittal, SK
关键词：
人类腺病毒（HAT）载体作为疫苗向量显示出巨大的潜力。临床前和临床研究表明，使用该系统，载体设计，强大的抗原表达和保护性免疫的可行性。然而，预计将腺病毒载体用于疫苗的目的是受到先前存在的载体免疫的限制，或者在第一次接种腺病毒载体后迅速发展。载体免疫使载体颗粒失活并迅速去除转导的细胞，从而限制了转基因表达的持续时间。由于较强的载体免疫力，随后使用同一载体的效率通常较低。为了规避这一限制，已经提出了非人类腺病毒载体作为替代媒介。除了具有免疫力外，这些矢量还具有载体的大多数吸引人特征。已经开发并研究了几种复制或复制缺陷的非人类腺病毒载体，并研究了它们作为疫苗交付载体的潜力。在这里，我们回顾了各种非人类腺病毒载体的设计和表征的最新进展，并讨论了它们对人类和动物疫苗接种的潜在应用。
Human adenoviral (HAd) vectors have demonstrated great potential as vaccine vectors. Preclinical and clinical studies have demonstrated the feasibility of vector design, robust antigen expression and protective immunity using this system. However, clinical use of adenoviral vectors for vaccine purposes is anticipated to be limited by vector immunity that is either preexisting or develops rapidly following the first inoculation with adenoviral vectors. Vector immunity inactivates the vector particles and rapidly removes the transduced cells, thereby limiting the duration of transgene expression. Due to strong vector immunity, subsequent use of the same vector is usually less efficient. In order to circumvent this limitation, nonhuman adenoviral vectors have been proposed as alternative vectors. In addition to eluding HAd immunity, these vectors possess most of the attractive features of HAd vectors. Several replication-competent or replication-defective nonhuman adenoviral vectors have been developed and investigated for their potential as vaccine-delivery vectors. Here, we review recent advances in the design and characterization of various nonhuman adenoviral vectors, and discuss their potential applications for human and animal vaccination.
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影响因子：
5.4
作者：
Chiocca, S;Baker, A;Cotten, M
通讯作者：
Cotten, M
影响因子：
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作者：
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通讯作者：
Both, GW
影响因子：
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作者：
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影响因子：
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作者：
Bangari, DS;Mittal, SK
通讯作者：
Mittal, SK
DOI：
10.1016/j.bbrc.2004.12.099
发表时间：
2005-02-18
影响因子：
3.1
作者：
Bangari, DS;Shukla, S;Mittal, SK
通讯作者：
Mittal, SK