Observation of choroidal circulation using index of erythrocytic velocity.
Observation of choroidal circulation using index of erythrocytic velocity.
复制标题
使用红细胞速度指数观察脉络膜循环。
DOI：
10.1001/archopht.121.2.225
复制
发表时间：
2003
影响因子：
--
通讯作者：
H. Fujii
中科院分区：
文献类型：
--
作者：
H. Isono;S. Kishi;Y. Kimura;Naoya Hagiwara;N. Konishi;H. Fujii
客观化
目的：描述一种利用红细胞速度无创显示脉络膜循环的方法。
方法
对9名志愿者进行了激光散斑血流图(LSFG)和吲哚青绿(ICG)血管造影。LSFG测量视网膜和脉络膜血管中红细胞的定量相对速度指数(归一化模糊[Nb]值)。我们平均了3次脉动的Nb值，并在1次脉动中制作了1.5 mm平方的合成Nb图。通过重叠5张相邻的地图，我们创建了3.0 mm平方的全景后极NB地图。比较全景图和ICG血管造影的血管构型。为了确定视网膜血管的影响，我们建立了2只猴的视网膜分支动脉阻塞模型，并比较了阻塞前后的全景图。
结果
NB图显示脉络膜和视网膜血管有搏动性血流。Nb图的血管模式对比度有所改善。ICG血管造影的脉络膜血管与NB图上的脉络膜血管相对应。视网膜分支动脉阻塞前后MAP中的血管模式变化不大。
结论
LSFG无创性地显示了脉络膜循环的血流动力学，血管形态以脉络膜为主，与ICG血管造影相当。
临床相关性
LSFG可用于评价各种脉络膜疾病的脉络膜血流动力学。
OBJECTIVE
To describe a noninvasive method to visualize choroidal circulation by means of erythrocytic velocity.
METHODS
Laser speckle flowgraphy (LSFG) and indocyanine green (ICG) angiography were performed on 9 volunteers. The LSFG measures the quantitative relative velocity index of erythrocytes (normalized blur [NB] value) in retinal and choroidal vessels. We averaged NB values from 3 pulsations and made composite 1.5-mm-square NB maps during 1 pulsation. By overlapping 5 adjacent maps, we created a panoramic 3.0-mm-square NB map of the posterior pole. The vascular patterns of the panoramic map and ICG angiography were compared. To determine the influence of retinal vessels, we induced branch retinal artery occlusion in 2 monkey eyes and compared the panoramic maps before and after occlusion.
RESULTS
The NB map showed pulsatile blood flow in choroidal and retinal vessels. Vascular pattern contrast was improved in the NB map. Choroidal vessels in ICG angiography corresponded to those in the NB map. Vascular patterns in the map changed little before and after branch retinal artery occlusion.
CONCLUSIONS
The LSFG noninvasively visualized the hemodynamics of choroidal circulation, and the vascular pattern, which is mainly choroidal in origin, was comparable with that of ICG angiography.
CLINICAL RELEVANCE
The LSFG may be used to evaluate choroidal hemodynamics in various choroidal diseases.
影响因子：
4.4
作者：
J. Grunwald;S. Hariprasad;J. Dupont;M. Maguire;S. Fine;A. Brucker;A. Maguire;A. Ho
通讯作者：
J. Grunwald;S. Hariprasad;J. Dupont;M. Maguire;S. Fine;A. Brucker;A. Maguire;A. Ho
影响因子：
4.4
作者：
Riva,CE;Cranstoun,SD;Grunwald,JE;Petrig,BL
通讯作者：
Petrig,BL