Associations between recent and established ophthalmic conditions and risk of Alzheimer's disease.
Associations between recent and established ophthalmic conditions and risk of Alzheimer's disease.
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DOI：
10.1016/j.jalz.2018.06.2856
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Crane PK
中科院分区：
文献类型：
--
作者：
Lee CS;Larson EB;Gibbons LE;Lee AY;McCurry SM;Bowen JD;McCormick WC;Crane PK
识别与阿尔茨海默病 (AD) 风险增加相关的眼科疾病可能有助于更好地筛查和了解有 AD 风险的人。青光眼、年龄相关性黄斑变性 (AMD) 和糖尿病性视网膜病变 (DR) 的诊断基于《国际疾病分类》第 9 版修订版，以及成人思维变化研究中 3877 名参与者的代码。对最近（5 年内）和已确定（> 5 年）诊断的可能或可能发生 AD 的调整后风险比进行了评估。在超过 31,142 人年的随访中，发生了 792 例 AD 病例。最近确定的青光眼风险比分别为 1.46 (P = .01) 和 0.87 (P = .19)，AMD 风险比分别为 1.20 (P = .12) 和 1.50 (P < .001)，DR 风险比分别为 1.50 (P = .045) 和 1.50 (P = .03)。最近的青光眼诊断、既定的 AMD 诊断以及最近和既定的 DR 均发现 AD 风险增加。患有某些眼科疾病的人可能会增加 AD 风险。
Identifying ophthalmic diseases associated with increased risk of Alzheimer’s disease (AD) may enable better screening and understanding of those at risk of AD. Diagnoses of glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy (DR) were based on International Classification of Diseases, 9th revision, codes for 3877 participants from the Adult Changes in Thought study. The adjusted hazard ratio for developing probable or possible AD for recent (within 5 years) and established (>5 years) diagnoses were assessed. Over 31,142 person-years of follow-up, 792 AD cases occurred. The recent and established hazard ratio were 1.46 (P = .01) and 0.87 (P = .19) for glaucoma, 1.20 (P = .12) and 1.50 (P < .001) for AMD, and 1.50 (P = .045) and 1.50 (P = .03) for DR. Increased AD risk was found for recent glaucoma diagnoses, established AMD diagnoses, and both recent and established DR. People with certain ophthalmic conditions may have increased AD risk.
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DOI：
10.1016/j.jalz.2017.04.011
发表时间：
2017-12
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Crane PK;Trittschuh E;Mukherjee S;Saykin AJ;Sanders RE;Larson EB;McCurry SM;McCormick W;Bowen JD;Grabowski T;Moore M;Bauman J;Gross AL;Keene CD;Bird TD;Gibbons LE;Mez J;Executive Prominent Alzheimer's Disease: Genetics and Risk Factors (EPAD:GRF) Investigators
通讯作者：
Executive Prominent Alzheimer's Disease: Genetics and Risk Factors (EPAD:GRF) Investigators
预测2型糖尿病患者10年痴呆风险的风险评分：一项队列研究。
影响因子：
44.5
作者：
Exalto, Lieza G.;Biessels, Geert Jan;Karter, Andrew J.;Huang, Elbert S.;Katon, Wayne J.;Minkoff, Jerome R.;Whitmer, Rachel A.
通讯作者：
Whitmer, Rachel A.
影响因子：
3.7
作者：
Chung SD;Lee CZ;Kao LT;Lin HC;Tsai MC;Sheu JJ
通讯作者：
Sheu JJ
影响因子：
39.2
作者：
Larson, EB;Wang, L;Kukull, W
通讯作者：
Kukull, W
影响因子：
158.5
作者：
Crane, Paul K.;Walker, Rod;Larson, Eric B.
通讯作者：
Larson, Eric B.