Incidence of cognitively defined late-onset Alzheimer's dementia subgroups from a prospective cohort study.
Incidence of cognitively defined late-onset Alzheimer's dementia subgroups from a prospective cohort study.
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DOI：
10.1016/j.jalz.2017.04.011
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Executive Prominent Alzheimer's Disease: Genetics and Risk Factors (EPAD:GRF) Investigators
中科院分区：
文献类型：
--
作者：
Crane PK;Trittschuh E;Mukherjee S;Saykin AJ;Sanders RE;Larson EB;McCurry SM;McCormick W;Bowen JD;Grabowski T;Moore M;Bauman J;Gross AL;Keene CD;Bird TD;Gibbons LE;Mez J;Executive Prominent Alzheimer's Disease: Genetics and Risk Factors (EPAD:GRF) Investigators
在典型的迟发性阿尔茨海默氏痴呆症中可能存在生物学相关的异质性。我们分析了一项前瞻性队列研究中晚发性阿尔茨海默氏痴呆患者的认知数据。我们确定了记忆、视觉空间功能、语言和执行功能的个体平均值。我们确定了相对于该平均值有重大损害的领域。我们比较了人口统计学，神经病理学和遗传学的研究结果，在相对损伤定义的组。在32,286人年的随访中，869人患上了阿尔茨海默氏症。有393例（48%）无实质性相对损害的域。一些参与者在记忆（148，18%），视觉空间功能（117，14%），语言（71，9%）和执行功能（66，8%）方面存在孤立的相对障碍。具有孤立相对记忆障碍的组具有更高的APOE ε4比例，更广泛的阿尔茨海默病相关神经病理学，以及更高的其他阿尔茨海默病痴呆遗传风险变体比例。认知亚组策略可以识别生物学上不同的阿尔茨海默氏痴呆症患者子集。
There may be biologically relevant heterogeneity within typical late-onset Alzheimer’s dementia. We analyzed cognitive data from people with incident late-onset Alzheimer’s dementia from a prospective cohort study. We determined individual averages across memory, visuospatial functioning, language, and executive functioning. We identified domains with substantial impairments relative to that average. We compared demographic, neuropathology, and genetic findings across groups defined by relative impairments. During 32,286 person-years of follow-up, 869 people developed Alzheimer’s dementia. There were 393 (48%) with no domain with substantial relative impairments. Some participants had isolated relative impairments in memory (148, 18%), visuospatial functioning (117, 14%), language (71, 9%), and executive functioning (66, 8%). The group with isolated relative memory impairments had higher proportions with APOE ε4, more extensive Alzheimer’s-related neuropathology, and higher proportions with other Alzheimer’s dementia genetic risk variants. A cognitive subgrouping strategy may identify biologically distinct subsets of people with Alzheimer’s dementia.
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影响因子：
3.2
作者：
Crane, Paul K.;Carle, Adam;Gibbons, Laura E.;Insel, Philip;Mackin, R. Scott;Gross, Alden;Jones, Richard N.;Mukherjee, Shubhabrata;Curtis, S. McKay;Harvey, Danielle;Weiner, Michael;Mungas, Dan
通讯作者：
Mungas, Dan
影响因子：
11.2
作者：
Sonnen, Joshua A.;Larson, Eric B.;Montine, Thomas J.
通讯作者：
Montine, Thomas J.
影响因子：
9.9
作者：
Beeri, M. S.;Schmeidler, J.;Silverman, J. M.
通讯作者：
Silverman, J. M.
影响因子：
39.2
作者：
von Elm, Erik;Altman, Douglas G.;Vandenbroucke, Jan P.
通讯作者：
Vandenbroucke, Jan P.
影响因子：
3.2
作者：
Gibbons, Laura E.;Carle, Adam C.;Mackin, R. Scott;Harvey, Danielle;Mukherjee, Shubhabrata;Insel, Philip;Curtis, S. McKay;Mungas, Dan;Crane, Paul K.
通讯作者：
Crane, Paul K.