A critical role for alpha4betadelta GABAA receptors in shaping learning deficits at puberty in mice.
A critical role for alpha4betadelta GABAA receptors in shaping learning deficits at puberty in mice.
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DOI：
10.1126/science.1184245
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发表时间：
2010-03-19
期刊：
影响因子：
--
通讯作者：
Smith SS
中科院分区：
文献类型：
--
作者：
Shen H;Sabaliauskas N;Sherpa A;Fenton AA;Stelzer A;Aoki C;Smith SS
The onset of puberty defines a developmental stage when some learning processes are diminished, but the mechanism for this deficit remains unknown. We found that, at puberty, expression of inhibitory α4βδ γ-aminobutyric acid type A (GABAA) receptors (GABAR) increases perisynaptic to excitatory synapses in CA1 hippocampus. Shunting inhibition via these receptors reduced N-methyl-D-aspartate receptor activation, impairing induction of long-term potentiation (LTP). Pubertal mice also failed to learn a hippocampal, LTP-dependent spatial task that was easily acquired by δ−/− mice. However, the stress steroid THP (3αOH-5α[β]-pregnan-20-one), which reduces tonic inhibition at puberty, facilitated learning. Thus, the emergence of α4βδ GABARs at puberty impairs learning, an effect that can be reversed by a stress steroid.
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DOI：
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