The importance of laminin at the blood-brain barrier.
The importance of laminin at the blood-brain barrier.
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DOI：
10.4103/1673-5374.373677
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发表时间：
2023-12
影响因子：
6.1
通讯作者：
Milner R
中科院分区：
文献类型：
--
作者：
Halder SK;Sapkota A;Milner R
血脑屏障是中枢神经系统血管的一种独特属性，它保护敏感的中枢神经系统细胞免受潜在有害血液成分的影响。这种屏障的机制基础是在多个水平上发现的，包括紧密结合邻近内皮细胞的粘附物和紧密连接蛋白，以及邻近周细胞、小胶质细胞和星形胶质细胞末端的影响。此外，血管基底膜的细胞外基质成分在建立和维持血脑屏障完整性方面发挥了关键作用，不仅提供了血脑屏障细胞附着的粘附性底物，而且还提供了强烈影响血管细胞行为的指导信号。细胞外基质蛋白层粘连蛋白是基底膜中含量最丰富的成分之一，多条证据表明，它在指导血脑屏障行为方面发挥着关键作用。在本文中，我们描述了层粘连蛋白及其受体的基本结构，这些分子在中枢神经系统血管中的表达模式，以及它们在疾病状态下是如何改变的，最重要的是，不同的层粘连蛋白亚型或其受体的基因缺失如何揭示这些分子对血脑屏障功能和完整性的贡献。最后，我们讨论了该领域中一些重要的悬而未决的问题，并提供了一些关键的杰出实验的“待办事项”清单。
The blood-brain barrier is a unique property of central nervous system blood vessels that protects sensitive central nervous system cells from potentially harmful blood components. The mechanistic basis of this barrier is found at multiple levels, including the adherens and tight junction proteins that tightly bind adjacent endothelial cells and the influence of neighboring pericytes, microglia, and astrocyte endfeet. In addition, extracellular matrix components of the vascular basement membrane play a critical role in establishing and maintaining blood-brain barrier integrity, not only by providing an adhesive substrate for blood-brain barrier cells to adhere to, but also by providing guidance cues that strongly influence vascular cell behavior. The extracellular matrix protein laminin is one of the most abundant components of the basement membrane, and several lines of evidence suggest that it plays a key role in directing blood-brain barrier behavior. In this review, we describe the basic structure of laminin and its receptors, the expression patterns of these molecules in central nervous system blood vessels and how they are altered in disease states, and most importantly, how genetic deletion of different laminin isoforms or their receptors reveals the contribution of these molecules to blood-brain barrier function and integrity. Finally, we discuss some of the important unanswered questions in the field and provide a “to-do” list of some of the critical outstanding experiments.
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影响因子：
7.1
作者：
Halder SK;Kant R;Milner R
通讯作者：
Milner R
影响因子：
8
作者：
Berndt, Philipp;Winkler, Lars;Haseloff, Reiner F.
通讯作者：
Haseloff, Reiner F.
影响因子：
64.8
作者：
COHEN, J;BURNE, JF;BARTLETT, P
通讯作者：
BARTLETT, P
DOI：
10.1083/jcb.201212032
发表时间：
2013-07-22
期刊：
The Journal of cell biology
影响因子：
--
作者：
Chen ZL;Yao Y;Norris EH;Kruyer A;Jno-Charles O;Akhmerov A;Strickland S
通讯作者：
Strickland S
DOI：
10.1097/00004647-199909000-00012
发表时间：
1999-09-01
影响因子：
6.3
作者：
Abumiya, T;Lucero, J;del Zoppo, GJ
通讯作者：
del Zoppo, GJ