Ability of a confocal scanning laser ophthalmoscope (TopSS) to detect early glaucomatous visual field defect
Ability of a confocal scanning laser ophthalmoscope (TopSS) to detect early glaucomatous visual field defect
复制标题
共焦扫描激光检眼镜 (TopSS) 检测早期青光眼视野缺损的能力
DOI：
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复制
发表时间：
2000
影响因子：
4.1
通讯作者：
C. Kee
中科院分区：
文献类型：
--
作者：
Byoung;C. Kee
目的评价共聚焦扫描激光检眼镜（TopSS）检测早期青光眼视野缺损的能力。方法对韩国正常人110只眼的视盘进行检查，根据视盘大小计算各变量的正常值。对80例韩国原发性开角型青光眼和正常张力型青光眼患者的一只眼应用5个最敏感的视盘变量来鉴别青光眼。只包括视盘大小为2.0-3.0 mm2，轮廓倾斜小于3°的眼睛。利用这些变量建立早期青光眼视野缺损的独特判别标准，并在三组视野丧失患者中计算其敏感性和特异性。结果：半深度面积、杯盘比（C/D）、神经视网膜边缘总面积（NRR）、体积、NRR局部变薄是5个最敏感的变量。青光眼的诊断标准如下：(1)NRR总面积减少，其他四个变量中有一个异常；(2)NRR总面积正常，NRR局部变薄，其他三个变量中有一个异常。这些标准对轻度视野受损患者的敏感性为89.7%，对中度或重度视野受损患者的敏感性为100%；特异性为89.1%。结论该鉴别标准对青光眼的诊断具有较高的敏感性和特异性，TopSS可用于青光眼视盘病变的早期检测。
AIMS To evaluate the ability of the confocal scanning laser ophthalmoscope (TopSS) to detect early glaucomatous visual field defect using our unique discriminant criteria. METHODS The optic discs of 110 eyes of normal Korean subjects were examined and normal values for each variable were obtained according to the size of the optic disc. The five most sensitive optic disc variables for discriminating glaucoma were then applied to one eye of 80 Korean subjects with primary open angle glaucoma or normal tension glaucoma. Only eyes with an optic disc size of 2.0–3.0 mm2 and a contour tilt of less than 3° were included. These variables were used to develop unique discriminant criteria for detecting early glaucomatous visual field defect and their sensitivity and specificity were calculated in three groups of patients with visual field loss. RESULTS The five most sensitive variables were half the depth area, cup/disc (C/D) ratio, total area of the neuroretinal rim (NRR), volume above, and localised thinning of the NRR. The following criteria were used to diagnose glaucoma: (1) total area of the NRR decreased and one of the other four variables abnormal, and (2) total area of the NRR normal, localised thinning of the NRR, and one of the other three variables abnormal. The sensitivity of these criteria was 89.7% in patients with a mildly impaired visual field and 100% in those with a moderately or severely impaired visual field; the specificity was 89.1%. CONCLUSIONS The discriminant criteria used had high sensitivity and specificity in the diagnosis of glaucoma and the TopSS can be useful in the early detection of changes in the glaucomatous optic disc.
使用共焦激光图像分析检测青光眼的结构损伤。
DOI：
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发表时间：
1996
期刊：
Investigative ophthalmology & visual science.
影响因子：
--
作者：
Uchida,H;Brigatti,L;Caprioli,J
通讯作者：
Caprioli,J
影响因子：
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作者：
QUIGLEY, HA;ADDICKS, EM;GREEN, WR
通讯作者：
GREEN, WR