Survival of the fittest: how Brucella strains adapt to their intracellular niche in the host.
Survival of the fittest: how Brucella strains adapt to their intracellular niche in the host.
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DOI：
10.1007/s00430-009-0123-8
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发表时间：
2009-11
影响因子：
5.4
通讯作者：
Martin DW
中科院分区：
文献类型：
--
作者：
Roop RM 2nd;Gaines JM;Anderson ES;Caswell CC;Martin DW
布鲁氏菌菌株会导致自然宿主流产和不孕，并导致人类患上称为波状热的人畜共患疾病。这些细菌不产生经典的毒力因子，它们在各种宿主细胞内成功生存和复制的能力强调了它们的致病性。布鲁氏菌在胎盘滋养层中的广泛复制与自然宿主的生殖道病理有关，并且巨噬细胞中的长期持续存在会导致慢性感染，这是自然宿主和人类布鲁氏菌病的标志。这篇综述描述了布鲁氏菌菌株如何有效地适应宿主的细胞内生活方式。
Brucella strains produce abortion and infertility in their natural hosts and a zoonotic disease in humans known as undulant fever. These bacteria do not produce classical virulence factors, and their capacity to successfully survive and replicate within a variety of host cells underlines their pathogenicity. Extensive replication of the brucellae in placental trophoblasts is associated with reproductive tract pathology in natural hosts and prolonged persistence in macrophages leads to the chronic infections that are a hallmark of brucellosis in both natural hosts and humans. This review describes how Brucella strains have efficiently adapted to their intracellular lifestyle in the host.
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影响因子：
3.1
作者：
Billard, E;Cazevieille, C;Gross, A
通讯作者：
Gross, A
影响因子：
3.1
作者：
Burkhardt, S;de Bagüés, MPJ;Köhler, S
通讯作者：
Köhler, S
影响因子：
3.1
作者：
Allen, CA;Adams, LG;Ficht, TA
通讯作者：
Ficht, TA
DOI：
10.1073/pnas.0400975101
发表时间：
2004-06-29
影响因子：
11.1
作者：
Boussau, B;Karlberg, EO;Andersson, SGE
通讯作者：
Andersson, SGE
影响因子：
3.1
作者：
Anderson, Eric S.;Paulley, James T.;Roop, R. Martin, II
通讯作者：
Roop, R. Martin, II