The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation.
The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation.
复制标题
炎症在抑郁症的核心特征中的作用：使用外源引起的炎症从范式发出的见解。
DOI：
10.1016/j.neubiorev.2018.09.006
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发表时间：
2018-11
影响因子：
8.2
通讯作者：
Bower JE
中科院分区：
文献类型：
--
作者：
Dooley LN;Kuhlman KR;Robles TF;Eisenberger NI;Craske MG;Bower JE
大量的证据表明炎症与抑郁症的发展有关。然而，抑郁症的异质性阻碍了人们理解、预防和治疗这种疾病的努力。这篇综合性综述的目的是总结炎症与抑郁症的核心特征之间的联系，这些特征比综合征本身表现出更多的同质性：对负面信息的反应过度，奖励处理改变，认知控制降低和躯体综合征。对于每个核心特征，我们首先简要概述其与抑郁症和神经生物学基础的相关性，然后回顾调查炎症潜在作用的证据。我们主要关注外源性炎症实验范例的发现。我们的结论是，炎症可能在对负面信息的过度反应，改变奖励反应和躯体症状中发挥作用。通过标准神经心理学测量评估，支持炎症对认知控制影响的证据较少。最后，我们讨论了未来的研究和建议，如何测试炎症的异质性精神疾病的发病机制中的作用的影响。
A wealth of evidence has implicated inflammation in the development of depression. Yet, the heterogeneous nature of depression has impeded efforts to understand, prevent, and treat the disease. The purpose of this integrative review is to summarize the connections between inflammation and established core features of depression that exhibit more homogeneity than the syndrome itself: exaggerated reactivity to negative information, altered reward processing, decreased cognitive control, and somatic syndrome. For each core feature, we first provide a brief overview of its relevance to depression and neurobiological underpinnings, and then review evidence investigating a potential role of inflammation. We focus primarily on findings from experimental paradigms of exogenously-induced inflammation. We conclude that inflammation likely plays a role in exaggerated reactivity to negative information, altered reward reactivity, and somatic symptoms. There is less evidence supporting an effect of inflammation on cognitive control as assessed by standard neuropsychological measures. Finally, we discuss implications for future research and recommendations for how to test the role of inflammation in the pathogenesis of heterogeneous psychiatric disorders.
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影响因子：
3.4
作者：
Alam, MN;McGinty, D;Szymusiak, R
通讯作者：
Szymusiak, R
影响因子：
16.2
作者：
ANKARCRONA, M;DYPBUKT, JM;NICOTERA, P
通讯作者：
NICOTERA, P
影响因子：
6.9
作者：
Addington, AM;Gallo, JJ;Eaton, WW
通讯作者：
Eaton, WW
DOI：
10.1146/annurev-clinpsy-050212-185608
发表时间：
2013-01-01
期刊：
ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 9
影响因子：
--
作者：
Borsboom, Denny;Cramer, Angelique O. J.
通讯作者：
Cramer, Angelique O. J.
影响因子：
3.7
作者：
Bower JE;Greendale G;Crosswell AD;Garet D;Sternlieb B;Ganz PA;Irwin MR;Olmstead R;Arevalo J;Cole SW
通讯作者：
Cole SW