Yoga reduces inflammatory signaling in fatigued breast cancer survivors: a randomized controlled trial.
Yoga reduces inflammatory signaling in fatigued breast cancer survivors: a randomized controlled trial.
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DOI：
10.1016/j.psyneuen.2014.01.019
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发表时间：
2014-05
影响因子：
3.7
通讯作者：
Cole SW
中科院分区：
文献类型：
--
作者：
Bower JE;Greendale G;Crosswell AD;Garet D;Sternlieb B;Ganz PA;Irwin MR;Olmstead R;Arevalo J;Cole SW
瑜伽是一种流行的身心疗法，已证明对心理，行为和功能结果有有益的影响。然而，很少有研究调查对炎症过程的影响。这项研究测试了一种假设，即专门为疲劳的乳腺癌幸存者设计的艾扬格瑜伽干预会导致炎症相关基因表达和促炎细胞因子活性的循环标志物减少。患有持续性癌症相关疲劳的乳腺癌幸存者被随机分配到12周的艾扬格瑜伽干预（n = 16）或12周的健康教育对照条件（n = 15）。在基线、干预后和3个月随访时收集血液样本，用于全基因组转录谱分析和生物信息学分析。还评估了血浆炎症标志物和唾液皮质醇。在基于启动子的生物信息学分析中，瑜伽组显示，与对照组相比，促炎性转录因子核因子κ B（NF-κB）的活性降低，抗炎性糖皮质激素受体的活性增加，cAMP反应元件结合蛋白（CREB）家族转录因子的活性降低（所有p <0.05）。对可溶性肿瘤坏死因子受体II（sTNF-RII）也有显著的干预作用，这是TNF活性的标志物;瑜伽组的sTNF-RII血浆水平保持稳定，而健康教育组的该标志物水平增加（p = 0.028）。在白细胞介素1受体拮抗剂中观察到类似的非显著性趋势（p = 0.16）。未观察到C反应蛋白（CRP）、白细胞介素6（IL-6）或昼夜皮质醇测量值的显著变化。为期12周的恢复性艾扬格瑜伽干预减少了持续疲劳的乳腺癌幸存者的炎症相关基因表达。这些研究结果表明，有针对性的瑜伽计划可能对该患者人群的炎症活动产生有益影响，对行为和身体健康具有潜在的相关性。ClinicalTrials.gov标识符：NCT 00727662。
Yoga is a popular mind-body therapy that has demonstrated beneficial effects on psychological, behavioral, and functional outcomes. However, few studies have investigated effects on inflammatory processes. This study tested the hypothesis that an Iyengar yoga intervention specifically designed for fatigued breast cancer survivors would lead to decreases in inflammation-related gene expression and circulating markers of proinflammatory cytokine activity. Breast cancer survivors with persistent cancer-related fatigue were randomized to a 12-week Iyengar yoga intervention (n = 16) or a 12-week health education control condition (n = 15). Blood samples were collected at baseline, post-intervention, and at a 3-month follow-up for genome-wide transcriptional profiling and bioinformatic analyses. Plasma inflammatory markers and salivary cortisol were also assessed. In promoter-based bioinformatics analyses, the yoga group showed reduced activity of the pro-inflammatory transcription factor nuclear factor kappa B (NF-κB), increased activity of the anti-inflammatory glucocorticoid receptor, and reduced activity of cAMP response element-binding protein (CREB) family transcription factors relative to controls (all ps < .05). There was also a significant intervention effect on the soluble tumor necrosis factor receptor type II (sTNF-RII), a marker of TNF activity; plasma levels of sTNF-RII remained stable in the yoga group, whereas levels of this marker increased in the health education group (p = .028). A similar, non-significant trend was observed for the interleukin 1 receptor antagonist (p = .16). No significant changes in C reactive protein (CRP), interleukin 6 (IL-6), or diurnal cortisol measures were observed. A 12-week restorative Iyengar yoga intervention reduced inflammation-related gene expression in breast cancer survivors with persistent fatigue. These findings suggest that a targeted yoga program may have beneficial effects on inflammatory activity in this patient population, with potential relevance for behavioral and physical health. ClinicalTrials.gov identifier: NCT00727662.
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影响因子：
10.6
作者：
Antoni, Michael H.;Lutgendorf, Susan K.;Blomberg, Bonnie;Carver, Charles S.;Lechner, Suzanne;Diaz, Alain;Stagl, Jamie;Arevalo, Jesusa M. G.;Cole, Steven W.
通讯作者：
Cole, Steven W.
影响因子：
5.8
作者：
Cole, SW;Yan, W;Zack, JA
通讯作者：
Zack, JA
DOI：
10.1111/j.1745-7599.2010.00573.x
发表时间：
2011-03-01
影响因子：
--
作者：
Banasik, Jacquelyn;Williams, Holly;Bendel, Robert
通讯作者：
Bendel, Robert
影响因子：
15.1
作者：
Fagundes, Christopher P.;Glaser, Ronald;Kiecolt-Glaser, Janice K.
通讯作者：
Kiecolt-Glaser, Janice K.
DOI：
10.1158/1078-0432.ccr-08-2584
发表时间：
2009-09-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Bower JE;Ganz PA;Tao ML;Hu W;Belin TR;Sepah S;Cole S;Aziz N
通讯作者：
Aziz N